壳聚糖二元酸盐抗菌机理的研究  

Study on the antibacterial mechanism of chitosan dicarboxylates

作　　者：梁兴泉[1] 王盾[1] 蒋作刚[1] 林宝凤[1] 

机构地区：[1]广西大学化学化工学院,广西南宁530004

出　　处：《广西大学学报（自然科学版）》2010年第3期394-398,共5页Journal of Guangxi University（Natural Science Edition）

基　　金：国家自然科学基金资助项目(50263001);广西自然科学基金资助项目(桂科配0135007);广西南宁市科技攻关项目(200901023A)

摘　　要：考察了壳聚糖二元酸盐对大肠杆菌的抗菌性能,初步探讨壳聚糖二元酸盐对大肠杆菌的抗菌机理,结果表明,壳聚糖二元酸盐的抗菌活性是通过与细菌细胞膜产生强烈相互作用而实现的,这种相互作用导致细菌细胞膜的通透性增加并失去完整性,细菌因细胞质外流,DNA等物质渗漏而死亡。The antibacterial activity and antibacterial mechanism of Chitosan dicarboxylates to Escherichia Coli were studied.The results showed that the chitosan dicarboxylates was of the antibacterial activity through the strong interaction between chitosan dicarboxylates and the cell membrane of Escherichia coli and this interaction led to the increase of permeability,losing the integrity of cell membrane,which reslted in the death of Escherichia coli due to the outflow of cytoplasm and DNA.

关 键 词：壳聚糖二元酸盐 抗菌 细胞膜 

分 类 号：TQ423.31[化学工程]