盐酸海地芬-壳聚糖微球的制备及其释药性能  

Study on preparation of Clomipramine Hydrochloride-Chitosan microsphere and its drug-releasing property

作　　者：蒋林斌[1] 易志远[1] 宁春园[1] 杨华[1] 张淑琼[1] 

机构地区：[1]广西大学化学化工学院,广西南宁530004

出　　处：《广西大学学报（自然科学版）》2010年第3期428-431,共4页Journal of Guangxi University（Natural Science Edition）

基　　金：广西自然科学基金资助项目(0832031);广西区教育厅科研基金项目(200807MS009)

摘　　要：以戊二醛作为交联剂,盐酸海地芬(CH)为模型药物,通过乳化-化学交联法制备了盐酸海地芬-壳聚糖微球,考察了其理化性质和释药性能。实验结果表明:盐酸海地芬-壳聚糖微球的外表规整,表面光滑,平均粒径7.8μm,载药量为3.4%,药物包封率为58%。该微球在酸性溶液中的释药速率要大于在碱性溶液中,且随壳聚糖(CS)浓度增大而减慢,随交联剂用量的增加而降低。By using Clomipramine Hydrochloride（CH）as the model drug,Clomipramine Hydrochloride-Chitosan（CS）microspheres were prepared by emulsification cross-linking technique with glutaraldehyde as a cross-linking reagent.The physicochemical property and the drug-release performances of the microspheres were investigated.The results showed that the microspheres had regular spherical shape with an average diameter of about 7.8 μm,the drug had a loading rate of 3.4% and a encapsulated rate of 58%.These microspheres had better slow release property in alkalescence solution than in acidic solution.With the increase of CS concentration and dosage of cross-linking reagent,the releasing ratio of microspheres decreased.

关 键 词：壳聚糖微球 盐酸海地芬 缓释 乳化交联 

分 类 号：O629.12[理学—有机化学]