重度创伤后血清肿瘤坏死因子α及白细胞介素6水平变化与感染性并发症的关系  

Relationship between the changes in serum levels of TNF-α and IL-6 and infectious complications after severe trauma

作　　者：田玉科[1] 罗爱林[1] 金士翱[1] 

机构地区：[1]同济医科大学附属同济医院麻醉科,武汉430030

出　　处：《中华实验外科杂志》1999年第1期38-39,共2页Chinese Journal of Experimental Surgery

基　　金：国家教委科研资助

摘　　要：目的探讨严重创伤后血清肿瘤坏死因子α（TNF-α）和白细胞介素6（IL-6）水平的变化与感染性并发症的相关性。方法选择80例重度多发性创伤患者，动态观察创伤当日，伤后第3、10、20天及出院的血清TNF-α、IL-6的变化。结果血清TNF-α水平的变化与重感染发生率之间的则关系数r=0.9095，P＜0.01；血清IL－6水平的变化与严重感染发生率之间的相关系数r=0.9770，P＜0.01结论重度创伤后细胞因子TNF-α及IL-6水平的升高程度与严重感染密切相关。Objective In order to evaluate the post-traumatic changes of serum levels of tumor necrosis factor α (TNF-α) and interleukin-6 (IL-6) and their relationship to the occurrence of infectious complications. Method The changes in serum TNF-α, IL-6 levels were observed on that day of injury, 3rd, 10th, and 20th day after injury, and the day before discharge in 80 adult patients with severe multiple trauma (SMT). Result The correlation coefficients between the levels of serum TNF-α, IL-6 and the severe infection incidence were r = 0. 9095, P < 0. 01, and r = 0. 9770, P < 0.01 respectiviy. Conclusion The increase of TNF-α and IL-6 levels in SMT patients might be closely related with severe infection.

关 键 词：创伤 感染 肿瘤坏死因子 白细胞介素6 

分 类 号：R641.06[医药卫生—外科学] R630.2[医药卫生—临床医学]