动态血压观察卡维地洛降压疗效  

Antihypertensive efficacy of carvedilol by ambulatory blood pressure monitoring

作　　者：唐家荣[1] 刘效锋 龚培力[3] 陆再英 

机构地区：[1]同济医科大学附属同济医院心内科,武汉430030 [2]武昌铁路中心医院内科 [3]同济医科大学临床药理研究所

出　　处：《临床心血管病杂志》1999年第1期40-42,共3页Journal of Clinical Cardiology

摘　　要：目的 :观察卡维地洛的降压疗效。方法 :服用安慰剂 10～ 14 d后服用卡维地洛 10～ 40mg/ d,上午 8时顿服 ,总疗程为 4周 ,共治疗轻中度原发性高血压 ( EH)患者 2 5例。采用血压监测仪测定 2 4h动态血压。结果 :治疗 4周后 2 4h平均血压、白昼及夜间平均血压、血压负荷值均较用药前显著下降 ( P <0 .0 1) ,收缩压和舒张压的谷 /峰比值分别降低 5 4.1%和 65 .6%。结论 :卡维地洛每日 1次投药能有效地控制轻中度 EH患者 2 4h血压水平。Objective:To observe the antihypertensive effect of carvedilol.Method:Ambulatory blood pressure monitoring was used to assess the antihypertensive efficacy of carvedilol.Twenty five cases (male 4,female 21,age 58±6 yrs)of mild to moderate hypertension were given carvedilol 10～40 mg once daily.The total course of treatment was 4 weeks.Result:The results showed that after treatment with carvedilol 22.4 ± 8.8 mg/d for 4 weeks,the 24 hours mean blood pressure,daytime and nighttime mean blood pressure,blood pressure load reduced significantly compared with that before treatment (P< 0.01 ).The trough peak ratio of carvedilol for systolic and diastolic blood pressure were 54.1 % and 65.6 %,respectively.Conclusion:Once daily (10～40 mg) carvedilol is effective in lowering blood pressure level of 24 hours in patients with mild to moderate hypertension.

关 键 词：高血压 卡维地洛 动态血压 降压 

分 类 号：R544.105[医药卫生—心血管疾病] R972.4[医药卫生—内科学]