冠状粥动脉样硬化性疾病患者肺炎衣原体抗体检测  

DETECTION THE ANTIBODIES TO CHLAMYDIA PNEUMONIAE IN CORONARY ATHEROSCLEROTIC HEART DISEASE

作　　者：袁佶[1] 余竹元[1] 黄士通[1] 

机构地区：[1]上海医科大学附属中山医院免疫室

出　　处：《中国人兽共患病杂志》1999年第1期12-13,11,共3页Chinese Journal of Zoonoses

摘　　要：目的为探索肺炎衣原体（Ｃｐｎ）和冠状动脉粥样硬化性心脏病之间的关系。方法应用间接微量免疫荧光试验分别检测了６１例冠心病患者与６１例正常对照组血清中抗ＣｐｎＩｇＧ和ＩｇＭ抗体。结果患者组ＩｇＧ抗体阳性率为７８．７％，对照组为５４．１％；ＩｇＭ抗体阳性率分别为２６．２％和６．６％。两组ＩｇＧ和ＩｇＭ抗体阳性率差异均有显著性（Ｐ＜０．０１）。此外，两组ＩｇＧ抗体的几何平均滴度差异尤具有显著性。Aim To investigate the relationship between Chlamydia pneumoniae(Cpn) and coronary atherosclerotic heart disease(CHD).Method The IgG and IgM antibody titers to Cpn in stored sera from 61 CHD patients and 61 healthy people was datected by microimmunofluorescence antibody technique.Results The positive rate of IgG antibody was 78 7% in CHD cases and 54 1% in controls;IgM antibody was 26 2% and 6 6% respectively.The differences of positive rate (IgG and IgM antibodies) were both found to be significant (P<0 01).In addition,a significant difference of the geometric mean titers(IgG antibody)between two groups was also found.Conclusion The results suggest that the Cpn infection may be associated with CHD.

关 键 词：肺炎衣原体 冠心病 抗体 检测 

分 类 号：R541.4[医药卫生—心血管疾病] R374[医药卫生—内科学]