瘦素对结核性与恶性胸腔积液的鉴别诊断价值  

Values of Serum and Fluid Leptin Contents in Differential Diagnosis of Tuberculous from Malignant Pleural Effusion

作　　者：朱涟敏[1] 历风元[1] 刘显峰[1] 

机构地区：[1]南昌大学第三附属医院呼吸内科,南昌330008

出　　处：《南昌大学学报（医学版）》2010年第2期75-76,78,共3页Journal of Nanchang University：Medical Sciences

摘　　要：目的探讨血清、胸腔积液中的瘦素水平对结核性与恶性胸腔积液的鉴别诊断价值。方法选取结核性、恶性胸腔积液住院患者各20例,同时选取20例健康体检者为对照组。采用ELISA法测定血清、胸腔积液中瘦素含量。结果结核性胸腔积液组血清及胸腔积液瘦素水平均低于恶性胸腔积液组,差异均有统计学意义(P<0.05);结核性胸腔积液组与恶性胸腔积液组血清瘦素水平均较对照组低,差异有统计学意义(P<0.05)。结论血清、胸腔积液瘦素水平对结核性、恶性胸腔积液的鉴别诊断具有一定的价值,可作为两者鉴别的指标之一。Objective To investigate the values of the leptin in fluid and serum in the differential diagnosis of tuberculous and malignant pleural effusion.Methods Serum and pleural fluid specimens were simultaneously collected from 40 patients（benign tuberculosis 20,malignant 20）,besides 20 health controls.Leptin contents were determined by ELISA.Results Serum and pleural leptin levels in patients with tuberculosis pleural effusion were significantly lower than those in malignant pleural effusion（P0.05）.Serum leptin in patients with tuberculous and malignant pleural effusion were lower than those in healthy controls（P0.05）.Conclusion Leptin levels of serum and pleural effusion were a certain value in the differential diagnosis of tuberculous pleural effusion from malignant pleural effusion,could be used as one of the identified indicators.

关 键 词：瘦素 胸膜炎 肺结核 恶性肿瘤 

分 类 号：R561[医药卫生—呼吸系统]