采用光学相干断层成像技术评价海利欧斯雷帕霉素洗脱支架术9个月后内膜覆盖情况  

Evaluation of Neointimal Coverage 9 Months After Helios Sirolimus-Eluting Stent Implantation by Optical Coherence Tomography

作　　者：宋现涛[1] 杜梦阳[1] 陈欣[1] 苑飞[1] 周玉杰[2] 吕树铮[1] 陈韵岱[3] 

机构地区：[1]首都医科大学附属北京安贞医院心内科,北京市100029 [2]首都医科大学附属北京安贞医院干部病房,北京市100029 [3]解放军总医院心内科,北京市100853

出　　处：《中国动脉硬化杂志》2010年第4期287-290,共4页Chinese Journal of Arteriosclerosis

基　　金：北京市科委高科技战略主题计划资助项目(D0906006040191);北京市科技新星计划资助项目(2007A001)

摘　　要：目的应用光学相干断层成像评价国产雷帕霉素洗脱支架置入后支架内血管新生内膜的生长情况,并能对患者的双重抗血小板药物治疗疗程提供依据。方法对10例置入海利欧斯药物洗脱支架患者术后常规抗血小板治疗9个月后行冠状动脉血管内光学相干断层成像检查,间隔1mm测量每个截面中支架小梁的新生内膜覆盖情况。结果总共测量296mm长度支架阶段的2063个支架小梁,支架血管内膜无覆盖率是64.6%,有内膜覆盖的平均内膜厚度是95.70±66.62μm,平均新生内膜面积的管腔百分比为5.0618%±5.6625%。结论海利欧斯洗脱支架植入9个月后内膜覆盖不良的比例较高,提示对于海利欧斯洗脱支架的随访时间应该更长,双联抗血小板治疗疗程也应该更长。Aim To determine optimal duration with dual antiplatelet therapy,optical coherence tomography （OCT） was used to assess neointimal coverage after implantation of sirolimus-eluting stents. Methods Stent strut intimal coverage at 9 months after Helios stent implantation was assessed by OCT at 1-mm intervals in 10 patients who accepted one year of dual antiplatelet therapy. Results Of 2 063 struts in 296 mm examined,64.6% had no intimal coverage. The average intimal thickness was 95.70±66.62 μm while average lumen percentage of neointimal area was 5.061 8%±5.662 5%. Conclusion The percentage of delayed intimal coverage was high at 9 months after Helios stent implantation,which suggested that duration of dual antiplatelet therapy should be prolonged after Helios stent implantation.

关 键 词：光学相干断层成像 雷帕霉素洗脱支架 支架内膜覆盖 新生内膜厚度 支架贴壁不良 

分 类 号：R5[医药卫生—内科学]