聚乙二醇α干扰素对慢性丙型肝炎患者血清IL-17、IL-10与TGF-β的影响及意义  

The Changes of Serum Levels and Clinical Significance of IL-17,IL-10 and TGF-β in Patients with Chronic Hepatitis C After Treatment of PEG-IFNα

作　　者：杨江华[1] 侯为顺[1] 杨利才[2] 杨进孙[1] 喻艳林[1] 

机构地区：[1]皖南医学院弋矶山医院感染性疾病科,芜湖241001 [2]皖南医学院弋矶山医院检验科,芜湖241001

出　　处：《临床消化病杂志》2010年第3期138-140,共3页Chinese Journal of Clinical Gastroenterology

基　　金：皖南医学院弋矶山医院引进人才基金;安徽省自然科学基金(NO.070413111);国家自然科学基金青年基金(NO.30700694)联合资助

摘　　要：目的探讨IL-17、IL-10及TGF-β在慢性丙型肝炎发病中的作用,观察聚乙二醇α干扰素抗病毒治疗对上述细胞因子水平的影响。方法采用ELISA法检测20例慢性丙型肝炎患者在聚乙二醇α干扰素治疗前后IL-17、IL-10和TGF-β的水平。结果慢性丙型肝炎患者IL-17和IL-10的水平均显著高于正常对照组(P<0.001),TGF-β水平在两组间无显著性差异。抗病毒治疗后,慢性丙型肝炎患者血清IL-17和IL-10的水平均较治疗前显著性下降(P<0.001)。结论 IL-17和IL-10共同参与了慢性丙型肝炎的发病,此结论对预测抗病毒疗效有指导意义。Objective To study the expression of serum IL-17,IL-10 and TGF-β in patients with chronic hepatitis C,and to investigate the changes of the three eytokines after treatment of PEG-IFNα. Methods The serum levels of IL-17,IL-10 and TGF-β in 20 patients with chronic hepatitis C before and after treatment of PEG-IFNα were determined by ELISA. Results The serum levels of IL-17, IL-10 and TGF-βin patients with chronic hepatitis C were significant higher than those in normal controls （ P 〈 0. 001 ）, the levels of IL-17, and IL-10 decreased obviously（ P 〈 0. 001 ） in responsive patients after treatment.-Conclu- sion IL-17 and IL-10 may participate in the pathogenesis of chronic hepatitis C and may be correlation with histological inflammation. The important clinical significance is showed in judging the result of antiviral treatment.

关 键 词：丙型肝炎 聚乙二醇α干扰素 白细胞介素-17 白细胞介素-10 转化生长因子-Β 

分 类 号：R512.63[医药卫生—内科学]