边缘系创伤反应性髓鞘碱性蛋白表达与超微结构观察  

The expression of trauma reactive myelin basic protein and observation of ultrastructure in limbic system

作　　者：王庆松[1] 嘉莉[1] 欧阳尧[1] 陈曼娥 

机构地区：[1]成都军区总医院神经内科 [2]成都军区总医院骨科 [3]第三军区大学大坪医院神经内科

出　　处：《中国病理生理杂志》1999年第1期36-38,共3页Chinese Journal of Pathophysiology

基　　金："九五"军队医药卫生科研基金

摘　　要：目的：探讨创伤反应性中枢神经系统（ＣＮＳ）间接受损的可能机制。方法：借助犬双后肢低、高速投射物致伤模型，观察了边缘系下丘脑、海马及颞顶区脑组织髓鞘碱性蛋白（ＭＢＰ）表达及超微结构改变。结果：伤后８ｈ低速组下丘脑ＭＢＰ－ｍＲＮＡ表达增强（Ｐ＜００１）；高速组下丘脑、海马ＭＢＰ含量明显增高（Ｐ＜００１），ＭＢＰ－ｍＲＮＡ表达增强（Ｐ＜００１）；超微结构改变以高速组下丘脑、海马为著，多集中于神经元、神经纤维及毛细血管内皮细胞变化。结论：边缘系下丘脑、海马选择性易损。AIM:To explore the probable mechanism of trauma reactive effects on the central nervous system(CNS).METHODS:On the basis of stress model with different velocity steel bullet injury to hind thighs of dogs,the expression of myelin basic protein(MBP) in limbic system,temporoparietal gray and white matters,and the early changes of their ultrastructure were observed.RESULTS:The expression of MBP-mRNA in hypothalamus in low speed group was significantly enhanced( P <0 05),MBP levels markedly increased( P <0 01) and the expression of MBP-mRNA was enhanced remarkably ( P <0 01) in hypothalamus and hippocampus in high speed group 8 hours after trauma; and the early pathomorphism changes displayed some alterations in neurons, nerve fibers and capillary endothelium cells of limbic system in high grouop. CONCLUSION:Hypothalamus and hippocampus were vulnerably damaged in spite of no direct injury to head,and these may play a consistent pathophysiological role in the development of trauma reactive central nervous system disturbance.

关 键 词：脊髓损伤 CNS 髓鞘碱性蛋白 超微结构 

分 类 号：R651.202[医药卫生—外科学]