利多卡因对兔内毒素性肺损伤晚期的治疗效应  

Therapeutic effects of lidocaine on the later phase of endotoxin-induced lung injury in rabbits

作　　者：李永荣[1] 郭贵林[1] 尹逊华[1] 安虹[1] 姚德厚[1] 

机构地区：[1]成都军区总医院

出　　处：《中国病理生理杂志》1999年第2期167-169,共3页Chinese Journal of Pathophysiology

摘　　要：目的：观察利多卡因对兔注射内毒素２４ｈ后的治疗效应。方法：用日本大耳白兔随机分为对照组、大肠杆菌内毒素（ＥＴ）组和ＥＴ注入后２４ｈ＋利多卡因（ｌｉｄｏｃａｉｎｅ）组。用酶联免疫法和硫代巴比妥酸反应法测量血浆和支气管肺泡灌洗液（ＢＡＬＦ）中ＴＮＦα和ＭＤＡ含量。结果：免静注ＥＴ后２４ｈ再静注利多卡因，于静注利多卡因后３、５ｈ，血浆和ＢＡＬＦ中ＴＮＦα和ＭＤＡ含量显著降低，血中性粒细胞数目明显回升。肺湿干重比值和ＢＡＬＦ中性粒细胞数、白蛋白含量、Ｃ３ａ、Ｃ５ａ浓度无明显变化。结论：内毒素肺损伤后（注ＥＴ后２４ｈ）用ｌｉｄｏｃａｉｎｅ仍可抑制脂质过氧化反应和炎症介质的释放。AIM:To investigate the therapeutic effects of lidocaine on the later phase of endotoxin-induced lung injury in rabbits. METHODS:Japan white rabbits were randomly assigned to receive one of the three treatments: infusion of saline (control group), infusion of Escherichia coli endotoxin (ET group), the later phase of endotoxin-induced lung injury with lidocaine treatment (ET+lidocaine group). The tumor necrosis factor-α(TNFα) and malondialdehyde (MDA) contents in plasma and bronchoalveolar lavage fluid (BALF) were analysed by ELISA and Satrh TBA method respectively.RESULTS:The later phase of endotoxin-induced lung injury with lidocaine atteuated the changes of TNFα and MDA contents in plasma and BALF. The wet-to-dry weight ratio in the lung did not change and neutropils cell counts, albumin, C3a and C5a concentration in BALF did not change significantly as compared with ET group. CONCLUSION:In the later phase of endotoxin-induced lung injury lidocaine still inhibited lipoperoxidation and releases of the inflammatory mediators, and attenuated endotoxin-induced lung injury in rabbits.

关 键 词：内毒素 利多卡因 肺损伤 药物疗法 兔 

分 类 号：R563.05[医药卫生—呼吸系统] R971.2[医药卫生—内科学]