妊娠期高血压疾病患者血浆总同型半胱氨酸水平与叶酸和维生素B_(12)的关系  

Determination of Plasma Homocysteine and Its Relationship with Folic Acid and Vitamin B_(12) in Patients with Hypertensive Disorder Complicating Pregnancy

作　　者：彭颖[1] 周湧[1] 黄素然[2] 萧丽娟[2] 

机构地区：[1]广东省东莞市太平人民医院,广东东莞523900 [2]广东省东莞市人民医院,广东东莞523018

出　　处：《今日药学》2010年第6期51-53,共3页Pharmacy Today

基　　金：广东省科技计划基金资助项目(编号:2007B080702046)

摘　　要：目的测定妊娠期高血压疾病患者血浆总同型半胱氨酸(tHCY)、血清叶酸和维生素B12水平,以探讨轻、重度患者3者之间的相互关系。方法用荧光偏振免疫分析法测定血浆tHCY水平,离子捕捉免疫分析法测定血清叶酸水平,微粒子酶联免疫分析法测定血清维生素B12水平。结果 232例妊娠期高血压疾病患者血浆tHCY水平、血清叶酸和维生素B12水平分别为(12.46±3.98)μmol/L,(11.81±3.39)nmol/L和(352.35±97.67)pmol/L,232例正常同期妊娠妇女血浆tHCY水平、血清叶酸和维生素B12水平分别为(6.71±2.43)μmol/L,(15.65±4.77)nmol/L和(438.63±129.45)pmol/L,2组比较均有显著性差异(P<0.01)。97例重度患者血浆tHCY水平、血清叶酸和维生素B12水平分别为(15.07±5.21)μmol/L,(9.52±2.66)nmol/L和(315.29±84.18)pmol/L,135例轻度患者tHCY水平、血清叶酸和维生素B12水平分别为(10.28±3.74)μmol/L,(13.16±4.83)nmol/L和(390.23±114.35)pmol/L,2组比较均有显著性差异(P<0.01)。相关分析显示,2组血浆tHCY水平与血清叶酸、维生素B12水平均呈负相关性。结论妊娠期高血压疾病患者血浆tHCY浓度显著上升,血清叶酸、维生素B12浓度显著下降。随着病情的加重,妊娠期高血压疾病患者血浆tHCY浓度呈逐渐上升趋势,血清叶酸、维生素B12浓度呈逐渐下降趋势。Objective To explore the relationship between plasma homoeysteine level and serum relic acid or vitamin B;2 status in the patients with hypertensive disorder complicating pregnancy of lightness or severity. Methods Total plasma homoeysteine （tHCY） level was determined by fluorescence polarization immunoassay （FPIA）. Serum relic acid level was measured by ion capture immunoassay （ ICIA ）. Vitamin B12 （ vitB12 ） level was measured by micropartiele enzyme immunoassay （MEIA）. Results The mean levels of tHCY, folie acid and vitB12 in 232 patients wflh hypertensive disorder complicating pregnancy were （ 12.46 ± 3.98） pomol/L, （ 11. 81 ± 3.39） nmol/L, and （352.35 ± 97.67） pmol/L respectively. The mean levels of tHCY, folio acid, and vitB12 in 232 normal pregnancy were （6.71 ± 2.43）ixmol/L, （15.65 ±4.77） nmol/L, and （438.63 ± 129.45） pmol/L respectively. There were significant differences between 2 groups （P 〈0.01 ）. The mean levels of tHCY, folio acid, and vitB12 in 97 patients of severity were （ 15.07 ± 5.21 ） pomol/L, （9. 52 ±2.66） nmol/L, and （315.29 ± 84.18） pmol/L respectively. The mean levels of tHCY, folio acid, and vitB12 in 135 paiients of lightness were （ 10.28 ±3.74） ） pomol/L, （ 13.16 ±4.83） nmol/L and （390.23± 114.35） pmol/L,respectively. There were significant differences between 2 groups （ P 〈 0.01 ）. Correlation analysis showed that plasma tHcy was negatively correlated with serum folic acid and vitB12. Conclusion The levels of plasma tHcy in patients with hypertensive disorder complicating pregnancy were significantly increased, and the levels of serum folic acid and vitB12 were significantly decreased. In patients with hypertensive disorder complicating pregnancy, there is a trend that the level of plasma tHcy increased with the severity of hypertensive disorder complicating pregnancy, while the levels of serum folic acid and vitB12 decreased with severity of hypertensive disorder complicating pregnancy.

关 键 词：妊娠期高血压疾病 同型半胱氨酸 叶酸 维生素B12 

分 类 号：R714.246[医药卫生—妇产科学]