羟基磷灰石/生物高分子复合材料的制备方法进展  

Research progress of preparation methods of hydroxyapatite/biopolymer composites

作　　者：杜江华[1,2] 

机构地区：[1]北方民族大学材料学院,宁夏回族自治区银川市750021 [2]西北工业大学理学院应用化学系,陕西省西安市710072

出　　处：《中国组织工程研究与临床康复》2010年第25期4717-4720,共4页Journal of Clinical Rehabilitative Tissue Engineering Research

基　　金：北方民族大学校内课题(2007Y042)~~

摘　　要：背景:羟基磷灰石/生物高分子复合材料克服了单一的生物陶瓷作为骨替代材料使用的脆性及加工困难的缺陷而成引起广泛的重视。目的:基于当前已发展的制备羟基磷灰石/生物高分子材料的方法有共混法、原位复合法、纤维复合法、仿生矿化法、电化学沉积法等,现对这些制备方法的优势与不足做一综述。方法:分别以英文检索词"hydroxyapatite(HA),composites,preparation";中文检索词"羟基磷灰石,复合材料,制备",应用计算机检索中国期刊网全文检索库(CNKI)及Elsevier数据库1996-01/2009-12有关文章,纳入羟基磷灰石/生物高分子复合材料的文献。排除与研究目的无关和内容重复者。保留31篇文献做进一步分析。结果与结论:目前,羟基磷灰石/生物高分子复合材料仍不完全能满足骨组织工程对材料的要求,需要进一步优化制备方法,增强羟基磷灰石和生物高分子界面的结合,提高复合材料的力学及加工性能;同时,精确控制其复合材料的微观结构与骨材料结构相近,使从而使材料同时具有优良的机械性能和生物学性能,达到临床使用的要求。BACKGROUND：The hydroxyapatite/biopolymer composites have attracted more attention since the composites can overcome the limitations of conventional bioceramic as bone substitutes such as brittleness and difficulty in shaping.OBJECTIVE：The current preparation methods of hydroxyapatite/biopolymer composites include mixing methods,in situ compositing,fiber reinforced compound method,bionic mineralization method,and so on,this study aims to review the advantages and disadvantages of the above described methods.METHODS：Using key words of ＂hydroxyapatite（HA）,composites,preparation＂ in English and ＂hydroxyapatite,composite materials,preparation＂ in Chinese,a computer search was performed in Chinese Periodical Full-text Database（CNKI） and Elsevier database between January 1996 and December 2009,the literatures addressing hydroxyapatite/biopolymer composites were included,articles non-related to research aim and with repeated content were excluded.A total of 31 literatures were involved in further analysis.RESULTS AND CONCLUSION：At present,the hydroxyapatite/biopolymer composites is still not fully able to meet the requirements for bone tissue engineering materials,thus needing further optimization for the preparation methods to reinforce the interface between hydroxyapatite and biopolymer,and to improve the mechanical and processing performance of composite materials;meanwhile,precise controlling the microstructure of the composite material structure similar to bone material structure may make the materials have excellent mechanical properties and biological properties to achieve the requirements of clinical use.

关 键 词：羟基磷灰石 生物高分子 制备方法 复合材料 综述文献 

分 类 号：R318[医药卫生—生物医学工程]