磁共振动态增强对急性肾功能衰竭肾实质血流灌注的初步研究  

Preliminary experience of renal blood perfusion in acute renal failure with enhanced dynamic MRI

作　　者：刘铁滨[1] 王和平[1] 

机构地区：[1]湖南师范大学医学院,湖南长沙410013

出　　处：《中外医学研究》2010年第12期1-2,共2页CHINESE AND FOREIGN MEDICAL RESEARCH

基　　金：湖南省教育厅课题（编号：08C567）

摘　　要：目的 评估动态增强磁共振（MRI）检查对急性肾功能衰竭肾实质血流灌注评价的作用.方法 实验动物分为对照组和急性肾功能衰竭组,行肾脏动态增强MRI检查,测量各肾皮质及髓质的信号强度,绘出其平均信号强度-时间曲线,记录皮质、髓质的平均峰值（P）及峰值/达峰时间比（P/T）.结果 肾功能衰竭组皮质和髓质的信号峰值及峰值/达峰时间比（Pc,Pm,Pc/Tc,Pm/Tm）明显低于对照组,差异有统计学意义（Pc、Pc/Tc〈0.01,Pm、Pm/Tm〈0.05）.结论 动态增强MRI能够反映急性肾功能衰竭肾脏血流灌注的变化.Objective To assess the renal blood perfusion in the acute renal failure with dynamic contrast - enhanced MR1 technology. Methods A control group and an acute renal failure group of the animal were studied, dynamic contrast - enhanced MRI was used to obtain the mean signal intensity - time curves of both cortex and medulla of each kidney. Mean peak intensity value（P） and the P/Time to peak ratio at the cortex and medulla（Pc,Pm,Pc/Te,Pm/Tm） of each kidney were measured. Results Pc,Pm,Pc/Tc,Pm/Tm were lower significantly in the acute renal failure group than the control group （ Pc Pe/Te 〈 0. 01, Pm Pm/Tm 〈 0. 05 ）. Conclusion dynamic contrast - enhanced MRI scan can be used to assess the change of renal blood perfusion in acute renal failure.

关 键 词：磁共振成像 急性肾功能衰竭 血流灌注 

分 类 号：R692.5[医药卫生—泌尿科学]