吡格列酮对2型糖尿病患者微量白蛋白尿影响的观察  

Evaluate the effect of pioglitazone on microalbuminuria in type 2 diabetes patients

作　　者：白素琼 张克英[1] 彭小蓉[1] 

机构地区：[1]绵阳市人民医院,四川绵阳621000

出　　处：《中外医学研究》2010年第12期30-31,共2页CHINESE AND FOREIGN MEDICAL RESEARCH

摘　　要：目的 研究吡格列酮对2型糖尿病微量白蛋白尿的影响.方法 70例2型糖尿病伴微量白蛋白尿患者随机分成吡格列酮组和对照组,观察两组治疗前后空腹血糖、餐后2 h血糖、尿白蛋白排泄率、尿素氮及肌酐的变化.结果 与治疗前相比,吡格列酮组治疗后空腹血糖和餐后2 h血糖、尿白蛋白排泄率明显降低,差异有统计学意义（P〈0.05）;对照组治疗前、后上述指标的差异均无统计学意义（P〉0.05）;两组间的差异均有统计学意义（P〈0.05）;两组治疗前后尿素氮、肌酐的差异均无统计学意义（P〉0.05）.结论 吡格列酮能减少尿微量白蛋白.Objective To evaluate the effect of pioglitazone on microalbuminuria in type 2 diabetes patients. Methods 70 cases of type 2 diabetes patients with microalbuminuria were randomly divided into tbe pioglitazone group and the control group. Changes of fasting and 2 h postprandial blood glucose, urinary albumin excretion rate, urea nitrogen, creatinine were observed in the pioglitazone group and the control group before and after the trial. Results The fasting and 2 h postprandial blood glucose,urinary albumin excretion rate decreased obviously after treatment in the pioglitazone group （P 〈 0. 05 ）. There was no significant difference in the control group（ P 〉 0. 05 ）. There were significant differ- ences between the pioglitazone group and the control group （P 〈 0. 05 ）. There was no significant difference in the level of urea nitrogen, creatnine after treatment in both groups（ P 〉 0. 05 ）. Conclusion Pioglitazone can significantly reduce microalbuminuria.

关 键 词：吡格列酮 2型糖尿病 尿微量白蛋白 

分 类 号：R587.1[医药卫生—内分泌]