基于脱羧法的C—C键生成反应  

Decarboxylative C—C Bond Formations

作　　者：冯超[1] 刘赛文 彭圣明[1] 易兵[2] 邓国军[1] 

机构地区：[1]环境友好化学与应用教育部重点实验室湘潭大学化学学院,湘潭411105 [2]湖南工程学院化学化工学院,湘潭411104

出　　处：《化学进展》2010年第7期1403-1413,共11页Progress in Chemistry

基　　金：国家自然科学基金项目(No.20902076)资助

摘　　要：羧酸和羧基功能基团广泛存在于各类有机化合物中。活泼的羧酸衍生物在功能团转换和构建C—C键方面占有十分重要的地位。含羧基的化合物具有价廉且易制备的特点,通过脱羧反应形成新的C—C键为有机合成反应提供了一条新的反应途径。脱羧反应具有高度的选择性并且主要副产物为二氧化碳,因此通过脱羧反应来构筑新的化学键的方法是一种廉价﹑环境友好的合成路线。关于脱羧反应的文献综述已经有很多,本文仅对过去几年中基于脱羧法的C—C键生成反应的研究进展做一简要综述。Carboxylic acid or carboxylate groups are among the most common functionalities in organic molecules. Activated derivatives of carboxylic acids have long served as versatile connection points in derivatizations and in the construction of carbon frameworks. Carboxylic acids are cheap and highly available. Decarboxylative reaction provides a new approach for organic synthesis. The carboxylic acid functionality ensures the regioselectivity of the reaction and only carbon dioxide is produced as waste. Thus decarboxylative reactions meet the requirement of green chemistry and its application in organic synthesis is very promising. Many reviews have been published on decarboxylative reactions. This review mainly focuse on the progress of decarboxylative C-C bond formation during the past several years.

关 键 词：羧酸 脱羧反应 C—C键生成反应 绿色化学 

分 类 号：O622.5[理学—有机化学]