高分子负载催化剂的设计、合成及其在有机合成反应中的应用  

Polymer-Supported Catalysts Designing,Synthesis and Their Application on Organic Synthetic Reaction

作　　者：郑昌武[1] 柴卓[1] 赵刚[1] 

机构地区：[1]中国科学院上海有机化学研究所天然产物合成化学重点实验室,上海200032

出　　处：《化学进展》2010年第7期1442-1456,共15页Progress in Chemistry

基　　金：国家重点基础研究发展规划(973)项目(No.2010CB833200);国家自然科学基金项目(No.20172064;203900502;20532040);国家杰出青年科学基金项目(No.20525208)资助

摘　　要：发展可回收和可重复利用的催化剂是过去几十年研究的一个热点,在这篇综述中,我们简要介绍了高分子负载催化剂的设计和合成策略以及这些催化剂在各种不同有机反应中的深入应用。在很多情况下,这一策略显示了在产物分离以及昂贵催化剂回收和再利用上的显著优点。与没有负载的同类催化剂相比,高分子负载催化剂可以保持同样的催化活性。另外,发展可控结构、尺寸、外观以及可溶性的线型聚合或树枝状的手性催化剂对于它们在有机合成中的应用都具有非常重要的意义。通过有机、高分子以及材料化学家的共同努力,这一方法在跨学科间取得了很大的进展,这一发展对于决定载体的选择起到了很大的作用。因此,进一步发展高活性和高对映选择性的催化剂仍将是这一领域的重要目标和挑战。The development of recoverable and reusable catalysts has been the subject of research over past decades. In this review, we have outlined the strategies of designing, synthesis of polymer-supported catalysts and summarized recent developments in their extensive applications in various organic reactions. In many cases, this strategy has demonstrated its great advantage in simplifying the separation of products and recovery and reuse of the usually expensive catalysts while maintaining comparable catalytic performance to that of the unsupported parent catalysts. In addition, the development of a linear polymeric or dendronized chiral catalysts with tunable structure, size, shape and solubility will play an important role to their utility in organic synthesis. Significant progress could be reached from the developing an interdisciplinary expertise with contributions from organic, polymer and material chemists. Also, it is great importance in determining the choice of support. Therefore, the further developments of highly active and enantioselective catalysts will continue to be an important goal and challenge in this field.

关 键 词：聚合物负载催化剂 可回收催化剂 可重复使用催化剂 有机反应 

分 类 号：O63[理学—高分子化学] O621.25[理学—化学]