产复康对产后气虚血瘀证奶牛内皮素和一氧化氮的影响  

The effects of Chanfukang on the Endothelin and Nitric Oxide of Postpartum cows with Qi-deficiency and Blood Stasis

作　　者：严作廷[1] 王东升[1] 杨国林[1] 谢家声[1] 李世宏[1] 张世栋[1] 巩忠福[2] 

机构地区：[1]中国农业科学院兰州畜牧与兽药研究所,甘肃兰州730050 [2]中国兽医药品监察所,北京100081

出　　处：《安徽农业科学》2010年第14期7366-7368,7716,共4页Journal of Anhui Agricultural Sciences

基　　金：国家科技攻关项目奶业专项"奶牛主要疫病防治关键技术研究与产业化开发"子课题"预防奶牛子宫内膜炎中药或中西结合药剂的研制"(项目编号:2002BA518A04)资助

摘　　要：[目的]观察产复康对产后气虚血瘀证奶牛血管内皮细胞的影响,探讨产复康治疗气虚血瘀证的机理。[方法]选择试验奶牛58头,分为气虚血瘀证治疗组、气虚血瘀证对照组、健康用药组和健康未用药组。分别于分娩前后测定血浆内皮素(ET)和血清一氧化氮(NO)的含量。[结果]气虚血瘀证奶牛产后血浆中ET含量和血清中NO含量显著升高;产后10d,NO含量开始有所下降,与对照组没有显著差异,但ET含量仍显著高于健康对照组;服用产复康10d后,ET含量仍显著高于对照组,而NO含量与健康对照组没有显著性差异。[结论]产复康可能通过升高气虚血瘀证奶牛ET和降低NO含量改善奶牛产后气虚血瘀证状态。[Objective]The research aimed to observe the effects of Chanfukang on the vascular endothelial cells of postpartum cows with qi-deficiency and blood stasis,and to explore the treatment mechanism of Chanfukang. [Method]A total of 58 cows were divided into qi-deficiency and blood stasis treated group,qi-deficiency and blood stasis control group,health treated group and health control group. The content of plasma endothelin （ET） and that of serum nitric oxide （NO） were measured before and after parturition,respectively. [Result]The contents of plasma ET and decreasing. that of serum NO were significantly increased in qi-deficiency and blood stasis control group compared with the health control group. The content of NO was decreased on day 10 after parturition in qi-deficiency and blood stasis control group,but the content of ET was still obviously higher than that in health control group. After taking Chanfukang for 10 d,the NO content were decreased,and there no significant difference between qi-deficiency and blood stasis treated group and health control group. [Conclusion]The Chanfukang maybe improve the postpartum cows with qi-deficiency and blood stasis through increasing the contents of ET in plasma and decreasing that of NO in serum.

关 键 词：产复康 气虚血瘀证 奶牛 内皮素 一氧化氮 

分 类 号：S854[农业科学—临床兽医学]