硝普钠并多巴胺治疗重症充血性心力衰竭42例临床观察  

THERAPEUTIC EFFECT OF SODIUM NITROPRUSSIDE AND DOPAMINE IN PATIENTS WITH SEVERE CONGESTIVE HEART FAILURE

作　　者：谢宇曦[1] 刘芳[1] 

机构地区：[1]唐山钢铁集团有限责任公司医院,唐山063000

出　　处：《现代预防医学》2010年第15期2952-2953,2955,共3页Modern Preventive Medicine

摘　　要：[目的]探讨硝普钠联合多巴胺在重症充血性心力衰竭治疗中的临床疗效。[方法]81例重症充血性心力衰竭患者,在吸氧、强心剂、利尿剂等常规治疗方法的基础上,随机分为两组,硝普钠联合多巴胺组(观察组)42例,多巴胺应用组(对照组)39例,治疗前后患者评估两组疗效,超声心动图检查心率、心脏收缩压、舒张压、LVDS及LVDD等心功能指标变化。[结果]硝普钠并多巴胺观察组显效、总有效率分别为64.3%、90.5%,显著高于对照组(P﹤0.05);联合用药组治疗后,各心功能指标均得到显著改善,与治疗前相比,具有极显著性差异(P﹤0.01)。[结论]硝普钠联合多巴胺治疗重症充血性心力衰竭具有一定的协同效果,可改善心肌收缩能力,减轻心脏负荷,且不会增加副作用,具有较好应用前景。[ Objective] To investigate clinical effect of using sodium nitmprusside and dopamine in severe congestive heart failure. [Methods] 81 patients with severe congestive heart failure, treated by convenEtonal treatment methods such as oxygen, digitalis, diuretics and other methods, were randondy divided into two groups： sodium nitroprusside with dopamine in 42 cases （observation group）, and dopamine in 39 cases （control group）. Assessed the therapeutic effect in patients before and after treatment such as heart rate, echocardiography, cardiac systolic and diastolic blood pressure, LVDS, LVDD and other indicators in cardiac function. [ Results] The effective rate and the total effective rate of observation group was 64.3% and 90.5% respectively, significantly higher （P 〈 0.05） than those of control group; The cardiac function parameters in combined treatment group were significantly improved, and the difference was significant （P 〈 0.01 ）. [ Conclusion] Nitmprusside combined with dopamine in the treatment of severe congestive heart failure has a synergistic effect which ean improve myocardial contractility and reduce cardiac stress, and will not increase the side effects.

关 键 词：心力衰竭 充血性 硝普钠 多巴胺 

分 类 号：R541.6[医药卫生—心血管疾病]