心血管支架置入后循环血中内皮素1的变化与血管内再狭窄  

Relationship between endothelin-1 level changes and intravascular restenosis following cardiovascular stent implantation

作　　者：卜煌[1] 

机构地区：[1]阜新市中心医院内科,辽宁省阜新市123000

出　　处：《中国组织工程研究与临床康复》2010年第26期4885-4888,共4页Journal of Clinical Rehabilitative Tissue Engineering Research

摘　　要：目的:探讨心脏支架置入过程中及置入后宿主内皮素1水平的变化及与血管内再狭窄的关系。方法:由第一作者应用计算机检索维普数据库,检索时限为1994-01/2009-10。检索关键词:支架植入;再狭窄;内皮素1;药物洗脱支架。共保留相关文献22篇进行分析。结果:内皮素1是目前已知作用最强和效应最持久的内源性缩血管活性肽,它对全身血压、局部血流灌注、促有丝分裂及细胞增殖等具有重要作用。经皮冠状动脉腔内成形后再狭窄是一个内皮功能失调的过程,正常情况下内皮细胞释放的生长因子和生长抑制因子之间有一个动态平衡,经皮冠状动脉腔内成形后内皮细胞受到损伤,这一平衡被打破,结果生长刺激因子活性占优势,从而导致血管平滑肌细胞增殖、迁移,促进再狭窄的形成。结论:药物洗脱支架可有效地抑制宿主内皮素1水平升高,可能是预防再狭窄的机制之一。OBJECTIVE： To explore relationship between host endothelin-1 level changes and intravascular restenosis during and after hear stent implantation. METHODS： A computer-based online search of VIP database was performed for articles published between January 1994 and October 2009, with ＂stent implantation, restenosis, endothelin-1, drug-eluting stent＂ in Chinese. A total of 22 articles were analyzed. RESULTS： Endothelin-1 is the endogenous vasoconstriction peptide with strong and continuous effect. It plays an important role in general blood pressure, local blood flow perfusion, promotion of mitosis and cell proliferation. Restenosis following percutaneous tranluminal coronary angioplasty is a process of endothelium dysfunction. Under normal condition, endothelial cells-released growth factor maintains a dynamic balance with growth inhibiting factor. However, this balance is damaged by percutaneous tranluminal coronary angioplasty, resulting growth stimulating factor activation, leading to vascular smooth muscle cell proliferation, migration and promoting restenosis formation. CONCLUSION： Drug-eluting stent effectively inhibits host endothelin-1 increase, which may contribute to the prevention of restenosis.

关 键 词：冠状动脉 支架置入 内皮素1 药物洗脱支架 再狭窄 

分 类 号：R318[医药卫生—生物医学工程]