Analgesic effect of parecoxib and flurbiprofen axetil for patients undergoing laparoscopic cholecystectomy and their influences on platelet aggregation  

作　　者：JI Fu-hai JIN Xin YANG Jian-ping ZAN Li-li 

机构地区：[1]Department of Anesthesiology, First Affiliated Hospital of Soochow University, Suzhou, Jiangsu 215006, China [2]Department of Anesthesiology, Suzhou Municipal Hospital,Suzhou, Jiangsu 215008, China

出　　处：《Chinese Medical Journal》2010年第12期1607-1609,共3页中华医学杂志（英文版）

摘　　要：It is known that opioids produce postoperative analgesia, while it can also cause, especially in large doses, side effects like nausea, vomiting, constipation, syncope, skin itching, urinary retention and even respiratory inhibition. These factors have all greatly limited its clinical use for treating postoperative pain. Meanwhile, non-steroidal anti-inflammatory drugs （NSAIDs） play an increasingly important role in postoperative analgesia. Some studies suggest that NSAIDS may be neural protective in cerebral ischemic conditions.It is known that opioids produce postoperative analgesia, while it can also cause, especially in large doses, side effects like nausea, vomiting, constipation, syncope, skin itching, urinary retention and even respiratory inhibition. These factors have all greatly limited its clinical use for treating postoperative pain. Meanwhile, non-steroidal anti-inflammatory drugs （NSAIDs） play an increasingly important role in postoperative analgesia. Some studies suggest that NSAIDS may be neural protective in cerebral ischemic conditions.

关 键 词：PARECOXIB flurbiprofen axetil cyclooxygenase inhibitor ANALGESIA 

分 类 号：R686[医药卫生—骨科学]