吸烟与抵抗素水平关系的研究  

The Relationship Between Smoking and Plasma Resistin

作　　者：张林峰[1] 李莹[1] 赵连成[1] 顼志敏[2] 陈祚[1] 史平[3] 任福秀[3] 郭敏[1] 田野[1] 李瑶[1] 邹晓璇[1] 朱曼璐[1] 武阳丰[4,5] 

机构地区：[1]北京中国医学科学院北京协和医学院心血管病研究所阜外心血管病医院卫生部心血管防治研究中心,100037 [2]北京中国医学科学院北京协和医学院心血管病研究所阜外心血管病医院卫生部临床药理中心,100037 [3]北京市石景山区疾病预防控制中心 [4]北京大学医学部公共卫生学院 [5]乔冶(中国)中心

出　　处：《中国分子心脏病学杂志》2010年第3期134-138,共5页Molecular Cardiology of China

基　　金：国家自然科学基金(30471494;30901237);北京市与中央高校共建项目(XK100230447)

摘　　要：目的探讨吸烟与抵抗素水平间的关系。方法 2005年对北京市石景山区1258例研究对象(其中男性439例,女性819例)进行流行病学调查,系统收集吸烟、饮酒、体力活动水平、血压、血脂、血糖等心血管病危险因素资料,并采用酶联免疫吸附法测定研究人群血浆抵抗素水平。结果男性不吸烟者、戒烟者、吸烟者血浆中的抵抗素水平的中位数分别为2.78ng/ml、2.60ng/ml和2.25ng/ml(P=0.0034)。女性不吸烟者、戒烟者、吸烟者血浆中的抵抗素水平的中位数分别为2.98ng/ml、2.96ng/ml和2.56ng/ml(P=0.0035)。吸烟者的体重指数和腰围显著低于不吸烟者。线性回归结果显示在控制了年龄、饮酒、饮茶、体力活动、收缩压、血清总胆固醇、高密度脂蛋白胆固醇、甘油三酯、空腹血糖、高敏C反应蛋白的情况下,无论男性还是女性吸烟和抵抗素水平之间仍存在显著的关联,然而如在模型中进一步控制BMI或腰围则吸烟和抵抗素水平之间的关联显著减弱,不再具有统计学显著性。结论吸烟和抵抗素水平之间存在显著的关联,这种关联可能主要与吸烟者的体重较低有关。Objective To explore the association between smoking and plasma resistin.Methods A community based epidemiology survey was carried out in the residents in the Shijingshan district in Beijing in 2005.Data on risk factors of cardiovascular diseases including smoking and drinking habits, physical activity, systolic blood pressure （SBP）, diastolic blood pressure （DBP）, body mass index （BMI）, waist cirumference were collected.Serum total cholesterol （TC）, high density lipoprotein cholesterol （HDL-C）, triglyceride （TG）, fasting glucose, high sensitive C reactive protein （hs-CRP） and plasma resistin were determined.Results The data of 1258 participants （439 men and 819 women） were analyzed. The median of the plasma resistin for the non-smokers, ex-smokers and current smokers was 2.78 ng/ml, 2.60 ng/ml and 2.25 ng/ml for men respectively （P=0.0034）, and 2.98 ng/ml, 2.96 ng/ml and 2.56 ng/ml for women respectively （P=0.0035）. The body mass index and waist circumference of smokers were signifi cantly lower than nonsmokers in both men and women. After controlling for age, drinking, drinking tea, physical activity, SBP, DBP, TC, HDL-C, TG, fasting glucose and hs-CRP, the association between smoking and plasma resistin was still statistically signifi cant for both men and women. However, after including BMI or waist circumference in the model the association was not signifi cant either for men or for women. Conclusion Smoking is related to plasma resistin, however, the relationship may be mainly intermediated by lower body weight of smokers.

关 键 词：吸烟 抵抗素 流行病学 

分 类 号：R587.1[医药卫生—内分泌]