阿托伐他汀对急性冠脉综合征NT—proBNP的影响  

Effects of atorvastatin on N - Terminal fragment of the prohormone brain - type natriuretic peptide（ NT - proBNP） of acute coronary syndrome

作　　者：陶卫国[1] 梁转合[1] 陈华发[1] 朱可云[1] 

机构地区：[1]南方医科大学附属新会人民医院,529100

出　　处：《中国医学创新》2010年第18期3-5,共3页Medical Innovation of China

摘　　要：目的观察阿托伐他汀对急性冠脉综合征NT—proBNP的影响。方法100例急性冠脉综合征患者随机分为观察组和对照组。每组各50例，所有患者入院抽血检测血脂和NT—proBNP，观察组除给予一般治疗外加用阿托伐他汀，对照组只给予一般治疗。8周后重新检测血脂和NT-proBNP，8周治疗中随访所有患者冠脉事件情况（心绞痛、心肌梗死、死亡）。结果8周后观察组TC、LDL、NT—proBNP较观察组治疗前及对照组治疗后有显著性差异（P〈0．05）。8周内观察组心绞痛发生率显著少于对照组，统计学检验有显著性差异（P〈0．05）。结论阿托伐他汀治疗急性冠脉综合征能显著降低患者血脂，减少冠脉事件的发生。Objective To investigate the effect of Atorvastatin on the N - Terminal Fragment of the Prohormone Brain -Type Natriuretic Peptide（NT- proBNP） of Acute Coronary Syndrome（ACS）. Methods 100 ACS patients are randomly distributed survey group and control group, every group is 50 patients, all patients are examinated about lipid and NT - proBNP when enter hospital, treatment of survey group is include Atorvastatin and routine cure,but control group is only routine cure. All patients are examinated about lipid and NT- proBN after 8weeks,and visit patients about coronary event（ angina pectoris myocardial infarction and death）. Results Degree of TC LDL and NT - proBNP after 8 weeks is less than before treatment in survey group,and is less than after 8 weeks treatment in control group, it is significant statistics test, angina pectoris rate on survery group is less than control group after 8 weeks,it is significant statistics test. Conclusion It can reduce lipid of ACS patients by Atorvastatin treatment, and reduce coronary event stroke.

关 键 词：阿托伐他汀 急性冠脉综合征 NT—proBNP 

分 类 号：R543.3[医药卫生—心血管疾病]