壮骨颗粒对骨折愈合的影响  

THE EFFECT OF ZHUANGGU GRANULA ON THE UNION OF FRACTURE: AN ANIMAL EXPERIMENT REPORT

作　　者：詹金华[1] 陈德喜[1] 万修阳[1] 郎继孝[1] 李巍[1] 刘玉江[1] 

机构地区：[1]青岛大学医学院附属青岛市海慈医院骨伤科,山东青岛266033

出　　处：《齐鲁医学杂志》2010年第4期336-337,340,共3页Medical Journal of Qilu

摘　　要：目的探讨壮骨颗粒对骨折愈合的影响。方法新西兰大白兔42只,于兔左侧桡骨中段做3 mm骨缺损,然后随机分为壮骨颗粒组、伤科接骨片组和生理盐水组,术后1 d开始给药。在第4、6、8周进行X线观察,第4、8周行病理组织学检查。结果 X线片评分半定量分析显示,壮骨颗粒组骨折愈合速度明显快于伤科接骨片组和生理盐水组(F=8.97、10.44,q=2.599～10.391,P<0.05);壮骨颗粒组Ⅰ型胶原表达明显强于伤科接骨片组和生理盐水组(F=50.63、85.89,P<0.05)。结论壮骨颗粒有明显促进骨折愈合作用。Objective To study the influence of Zhuanggu granula on the union of fracture. Methods A 3 mm-width bone defect on the middle of left radial in 42 New-Zealand rabbits was created,which were randomized to Zhuanggu granula group（group A）,Shangke Jiegu tablet group（group B）,and normal saline group（group C）.Medication started from the first day after surgery.An X-ray examination was carried out 4th,6th,and 8th week,and histology check on 4th and 8th week. ResultsSemi-quantitative analysis of an X-ray film showed callus formation was faster in group A than that in both groups B and C（F=8.97,10.44;q=2.599-10.391;P0.05）,and collagen Ⅰexpressions in group A was also stronger than that in both groups B and C（F=50.63,85.89;P0.05）. Conclusion Zhuanggu granula possesses a manifest action to promote union of fracture.

关 键 词：壮骨颗粒 骨折愈合 动物实验 

分 类 号：R683.41[医药卫生—骨科学]