超大孔聚(苯乙烯-甲基丙烯酸缩水甘油酯)共聚微球的制备及孔结构的调控  

Preparation of Macroporous Poly(styrene-glycidyl methacrylate) Microspheres with Controlled Pore Structure

作　　者：李燕[1,2] 周炜清[1] 马光辉[1] 

机构地区：[1]中国科学院过程工程研究所生化工程国家重点实验室,北京100190 [2]中国科学院研究生院,北京100049

出　　处：《过程工程学报》2010年第3期608-612,共5页The Chinese Journal of Process Engineering

摘　　要：使用表面活性剂反胶团法制备超大孔聚(苯乙烯-甲基丙烯酸缩水甘油酯)[P(ST-GMA)]共聚微球,考察了功能单体GMA含量、油溶性表面活性剂、稀释剂、交联剂对微球孔径的影响.结果表明,随GMA含量增加,微球孔径显著增大;表面活性剂用量从1.6g增加到2.0g时,微球孔径由100nm增加到720nm;随稀释剂疏水性增强,微球孔径增大;交联剂用量由1.0g增加到2.0g,微球孔径由550nm变为100nm左右.在此基础上,通过条件优化合成了具有特定孔径的不同功能单体GMA含量的超大孔P(ST-GMA)共聚微球,可连接不同配基,用于色谱分离介质及酶的固定化.Macroporous poly（styrene-glycidyl methacrylate） microspheres [P（ST-GMA）] were prepared using surfactant reverse micelle swelling method. The effects of GMA content, surfactant amount, diluents, and crosslinking agent amount on the pore distribution in microspheres were investigated. The results showed that the pore sizes of microspheres were remarkably increased with increasing of content of GMA. When the surfactant amount was added from 1.6 g to 2.0 g, the pore sizes were correspondingly increased from 100 to 720 nm. Further more, the pore sizes were positively related to the hydrophobicity of diluents. In addition, with the crosslinking agent amount was increased from 1.0 g to 2.0 g, the pore sizes were significantly decreased from 550 to 100 nm. Under the optimization conditions, macroporous P（ST-GMA） microspheres with special pore sizes and different contents of GMA were synthesized. The obtained macroporous microspheres can be used to link various ligands and applied as chromatographic media, or be directly used to immobilize enzymes.

关 键 词：表面活性剂反胶团 超大孔共聚微球 孔结构 

分 类 号：TB383[一般工业技术—材料科学与工程] TQ317.4[化学工程—高聚物工业]