消瘿瘤合剂对实验性甲状腺肿小鼠FT3及TSH值的影响  

Effect of XiaoYingLiu Mixture on Mice's Medicine-induced Goiter's FT3 and TSH

作　　者：霍光[1] 刘岩[2] 

机构地区：[1]辽宁中医药大学,辽宁沈阳110032 [2]辽宁中医药大学附属医院,辽宁沈阳110032

出　　处：《辽宁中医药大学学报》2010年第7期198-199,共2页Journal of Liaoning University of Traditional Chinese Medicine

摘　　要：目的:观察消瘿瘤合剂对丙硫氧嘧啶造小鼠甲状腺肿模型的影响。方法:小鼠灌服丙硫氧嘧啶0.22mg/g,日1次,连续20天后,再灌服消瘿瘤合剂和优甲乐。观察小鼠饮食、饮水量,30天后处死,取血清测FT3、TSH,取小鼠甲状腺做病理。结果:丙基硫氧嘧啶可诱发小鼠甲状腺肿。消瘿瘤合剂组的血清TSH指数与丙硫组相比有明显下降,FT3指数略高于丙硫组。结论:消瘿瘤合剂的中医处方可以促进丙基硫氧嘧啶所致小鼠甲状腺肿后的TSH降低,FT3增加,进一步证实可以对丙基硫氧嘧啶所致小鼠甲状腺肿具有一定恢复作用。Objective：To study the effect of XiaoYingLiu mixture on mice＇s medicine-induced Goiter which be made model by Propylthiouracil.Methods：After give mice Propylthiouracil 0.22mg/g once everyday by intragastric tub 20 days,then XiaoYingLiu mixture and Euthyrox were given to mice.To study the dietary and drinking amounts of mice,after 30 days,the mice＇s FT3 and TSH were determined by radioimmunoassa,mice＇s thyroid were remove to obtain the pathologic result of cardiac muscles.Results：Propylthiouracil could cause Goiter of mice.The group of XiaoYingLiu mixture＇s exponent of the model mice blood serum＇s TSH were lower than the group of Propylthiouracil obviously,the exponent of the model mice＇s FT3 were higher than the group of Propylthiouracil.Conclusion：The study suggests that XiaoYingLiu mixture could reduce the exponent of TSH and could increase the exponent of FT3 of which mice＇s medicine-induced Goiter which be made model by Propylthiouracil.Further to prove that XiaoYingLiu mixture had some functions of recovery to mice＇s medicine-induced Goiter which be made model by Propylthiouracil.

关 键 词：消瘿瘤合剂 小鼠甲状腺肿 优甲乐 丙基硫氧嘧啶 

分 类 号：R322.51[医药卫生—人体解剖和组织胚胎学]