N-(末端三甲基硅苄基甘氨酸肽链)邻苯二甲酰亚胺的光诱导单电子转移成环反应  

Photoinduced Single Electron Transfer Cyclization Reactions of N-(Amidosilane terminated polybenzylglycine peptide chain)phthalimide

作　　者：金英学[1] 谭广慧[1] 赵俊明[1] 张鹏[1] 王丙南[1] 郑鹏[1] 

机构地区：[1]哈尔滨师范大学化学化工学院,哈尔滨150025

出　　处：《有机化学》2010年第6期860-864,共5页Chinese Journal of Organic Chemistry

基　　金：国家自然科学基金(No.20972036);黑龙江省教育厅海外学人科研基金(No.1152hq23);国家人事部留学人员科技活动择优(No.[2007]275)资助项目

摘　　要：以苄基甘氨酸为起始原料合成N-(末端三甲基硅苄基甘氨酸肽链)邻苯二甲酰亚胺(1).1在甲醇溶剂中光照发生单电子转移反应,生成分子内双自由基10,自由基偶合生成环聚甘氨酸肽化合物2.此反应产率好,区域选择性高.所有新化合物结构均经NMR和质谱验证.Benzylglycine was used as starting material for the synthesis of N-（amidosilane teminated polybenzylglycine peptide chain）phthalimide（1）.Irradiating methanol solution containing 1 is observed to promote formation of biradical 10.Then the biradical 10 copulates to give cyclopolyglypeptides 2 in high yield and high selectivity.The structures of all the new compounds were characterized by MS and NMR techniques.

关 键 词：光诱导 单电子转移 环肽化合物 合成 

分 类 号：O621.25[理学—有机化学]