Ugi/SmI_2还原反应合成N-取代β,γ-不饱和酰胺的研究  

A Facile Route to the Synthesis of N-Substituted β,γ-Unsaturated Amides by Ugi/SmI_2 Reduction

作　　者：于辉[1] 孙文亮[1] 高瑞[1] 章美束[1] 

机构地区：[1]同济大学化学系,上海200092

出　　处：《有机化学》2010年第6期890-893,共4页Chinese Journal of Organic Chemistry

基　　金：2009教育部留学回国人员科研启动基金资助项目

摘　　要：将α,β-不饱和醛、苯胺、乙酸和异腈的Ugi四组分反应产物在四氢呋喃中用SmI2/HMPA处理,可以得到碳链延长一位的β,γ-不饱和酰胺,方法简便,产率中等到良好.该反应涉及一个自由基脱氨基过程.A novel way to the synthesis of β,γ-unsaturated amides was explored by treating the Ugi adducts of α,β-unsaturated aldehydes,isocyanides,aniline and acetic acid with SmI2/HMPA in dry tetrahydrofuran at room temperature.The yields were moderate to good.This reaction involved the radical deamination of α-substituted amides.

关 键 词：异腈 UGI 多组分反应 二碘化钐 

分 类 号：O622.6[理学—有机化学]