抗肿瘤聚合物胶束制剂的设计策略  

Design Strategy of Anti-tumor Polymeric Micelles Formulation

作　　者：邵铖祎[1] 涂家生[1] 

机构地区：[1]中国药科大学药剂教研室,南京210009

出　　处：《药学与临床研究》2010年第3期286-290,共5页Pharmaceutical and Clinical Research

基　　金：国家科技支撑计划2008BAT55B03;国家新药创制科技重大专项2009zx09310-004

摘　　要：肿瘤是目前危害人类健康的重大疾病之一,而临床应用的抗肿瘤药大多数为疏水性药物,需要载体增溶后才能使用。聚合物胶束以其高度的增溶能力、较低的过敏反应发生率和较少的毒副作用正在引起人们的重视。本文介绍了聚合物胶束的材料选择依据,以及制备技术,并提出了一种新的胶束设计策略——双药载药胶束。Tumor is one of the important diseases threatening the health of human beings.Most of antitumor drugs used in clinical are hydrophobic ones and need to be solubilized by carriers.Polymeric micelles are attracting more attention for their powerful ability of solubilization,low occurrence of hypersensitivity and less side effects.Here we introduce the strategy of choosing polymers and the technology of preparing micelles.Moreover,we bring up a new design strategy of polymeric micelles,named as binary-drug loaded micelles.

关 键 词：抗肿瘤 聚合物胶束 设计 双药载药胶束 

分 类 号：R979.1[医药卫生—药品] TQ460.6[医药卫生—药学]