减轻体重对伴有糖耐量受损的超重及肥胖者代谢指标的影响  

Effect of weight loss on metabolic parameters in over-weight or obesity patients combined with impaired glucose tolerance

作　　者：刘彦君 肖婷 朱平 程玉霞 杨小平 曹东平 许樟荣 

机构地区：[1]解放军第三O六医院糖尿病中心,北京100101

出　　处：《中华健康管理学杂志》2010年第3期142-144,共3页Chinese Journal of Health Management

摘　　要：目的探讨减轻体重对于伴有糖耐量受损（IGT）的超重及肥胖者血糖、血脂、血压等代谢状况的影响。方法以降低体重为目标，由专门培训的医护人员对91例超重或肥胖的IGT患者进行生活方式跟踪指导，观察和分析减重对于超重及肥胖的IGT患者血糖、血脂、血压、肝功能、尿酸等代谢状况的影响，并对其效果进行评价。结果经过3个月的管理患者体重明显下降，同时腰围、空腹血糖、餐后血糖、收缩压、舒张压、谷草转氨酶均明显下降，差异有统计学意义（P〈0．05）。超重及肥胖患者体重分别平均下降1．8b及2．3kg，为减重前体重的2．37％及2．72％。2组患者血糖、血压均明显降低，在超重组腰围及谷草转氨酶也显著降低，而肥胖组患者腰围及谷草转氨酶未见到显著下降。结论合理减重对于伴有IGT超重及肥胖者的中心性肥胖、血糖、血压和脂肪肝有明显的改善，有益于逆转他们的多种代谢异常。短期体重控制对于超重患者代谢指标改善效果明显，对于肥胖患者可能需要更长时间和更大幅度的减重，才能见到明显效果。Objective To evaluate the effective of weight loss on blood glucose, lipid profile, and blood pressure in over-weight or obesity patients combined with impaired glucose tolerance （IGT）. Methods Body weight of 91 over-weight or obesity IGT patients were managed by doctors and nurses. Body weight, waist circumference, blood glucose, lipid profile, blood pressure and liver function of the patients were compared at 3 months with baseline. Results After 3 months＇ intervention,the levels of body weight,waist circumference, fasting plasma glucose, postprandial glucose, systolic blood pressure, diastolic blood pressure, and glutamic oxalacetic transaminase （GOT） , instead of triglyceride and high-density lipoprotein cholesterol （HDL-C） ,were significantly reduced. Over weight or obesity IGT patients saw a 1.8 and 2. 3 kg body weight loss, respectively. Decreased plasma glucose and blood pressure were found both in the over-weight group and in the obesity groups, but decreased waist circumference and GOT were found only in the over-weight patients. Conclusions Body-weight control may improve the blood glucose, blood pressure, central obesity, or fatty liver in over weight or obesity IGT patients. For those obesity patients, longer and stronger body weight control should be needed.

关 键 词：超重 肥胖症 代谢 

分 类 号：R587.1[医药卫生—内分泌]