疏血通注射液联合低分子肝素治疗原发性肾病综合征疗效观察  

Therapeutic Effect of Shuxuetong Injection Combined with Low Molecular Heparin for Nephrotic Syndrome

作　　者：陈江林[1] 刘德慧[1] 

机构地区：[1]赣州市人民医院肾内科,江西赣州341000

出　　处：《新中医》2010年第7期33-34,共2页New Chinese Medicine

摘　　要：目的:观察疏血通注射液联合低分子肝素治疗原发性肾病综合征的疗效。方法:将72例患者随机分成2组各36例,对照组采用一般对症处理及激素治疗;治疗组在对照组治疗基础上采用疏血通注射液及低分子肝素治疗。2组均治疗8周后观察疗效。结果:治疗组完全缓解率为47.2%,总有效率为88.9%。对照组完全缓解率为30.6%,总有效率为80.6%。2组完全缓解率及总有效率比较,差异均有显著性意义(P<0.05)。治疗组与对照组治疗后24小时尿蛋白定量、血浆白蛋白(Alb)、总胆固醇(TC)、甘油三酯(TG)、纤维蛋白原(Fb)与治疗前比较,差异有非常显著性或显著性意义(P<0.01,P<0.05);2组治疗后Cr与治疗前比较,差异均无显著性意义(P>0.05)。2组治疗后24小时尿蛋白定量、Alb、TC比较,差异有显著性或非常显著性意义(P<0.05,P<0.01)。结论:在常规应用激素的同时,加用疏血通注射液及低分子肝素治疗原发性肾病综合征患者,可明显提高疗效。Objective:To observe the therapeutic effect Shuxuetong Injection(SI) combined with low molecular heparin for nephrotic syndrome.Methods:Seventy-two nephrotic syndrome patients were equally randomized into treatment group and control group.The two groups were given routine symptomatic treatment and hormone therapy,and the treatment group received SI combined low molecular heparin additionally.After treatment for 8 weeks,the therapeutic effect in both groups was evaluated.Results:The cure rate was 47.2% and the total effective rate was 88.9% in the treatment group;in the control group,the cure rate was 30.6% and the total effective rate was 80.6%.The differences of cure rate and total effective rate were significant between the two groups(P < 0.05).After treatment,24-hour urine protein,albumin(Alb),total cholesterol(TC),triglyceride(TG) and fibrinogen(Fb) were improved in both groups(P < 0.05 or P < 0.01 compared with those before treatment).The difference of serum creatinine(Cr) was insignificant in both groups compared with that before treatment(P > 0.05).The differences of 24-hour urine protein,Alb and TC were significant between the two groups after treatment(P < 0.05 or P < 0.01).Conclusion:Shuxuetong Injection can enhance the therapeutic effect of low molecular heparin for nephrotic syndrome.

关 键 词：肾病综合征 中西医结合疗法 疏血通注射液 低分子肝素 

分 类 号：R692[医药卫生—泌尿科学]