海南黎族人群对氧磷酶2基因多态性的分布情况分析  

ANALYSIS OF POLYMORPHISM DISTRIBUTION OF PARAOXONASE 2 GENE IN HAINAN LI NATIONALITY

作　　者：阎国钢[1] 邬强[2] 钱士匀[2] 傅琼瑶[2] 吴洁[2] 范志刚[2] 裴华[2] 

机构地区：[1]海南医学院护理学系,海口571101 [2]海南医学院检验医学系,海口571101

出　　处：《现代预防医学》2010年第14期2604-2606,共3页Modern Preventive Medicine

基　　金：海南省自然科学基金项目(2008-30837)

摘　　要：[目的]分析海南黎族人群对氧磷酶2(paraoxonase 2,PON2)基因多态性的分布特点,为研究PON2相关性疾病的发病机制奠定基础。[方法]采用聚合酶链反应-限制性片段长度多态性分析技术对海南178名黎族无关健康个体进行PON2(148Ala/Gly及311Cys/Ser)基因多态性的分析,计算其基因频率分布,并与海南汉族及其他人群PON2等位基因的多态性进行比较。[结果]海南黎族健康人群PON2基因148、311位点存在多态性,基因频率分别为GG0.214、GA0.129、AA0.657、CC0.056、CS0.281、SS0.663;在两个位点上汉、黎族健康人群基因型频率分布存在着明显差异(P均﹤0.01)。[结论]汉、黎族健康人群之间PON2基因多态性的分布存在明显差异,具有种族差异性。[Objective] To analyze the genetic polymorphism of paraoxonase 2（PON2） in Hainan Li nationality and play a basis on the research of mechanisms of diseases associated with PON2.[Methods] PON2 gene polymorphism of 178 subjects of Li nationality unrelated healthy in Hainan area was researched with polymerase chain reaction-restriction fragment length polymorphism（PCR-RFLP）,calculated genotype frequencies and compared with the results from Han nationality and other population.[Results] Polymorphisms（148Ala /Gly and311Cys /Ser） of PON2 gene were existed in Li nationality,the genotype frequency were GG0.214,GA0.129,AA0.657,CC0.056,CS0.281 and SS0.663,respectively;The frequencies of the PON2 genotype were significantly different between Hainan Han and Li nationality（P﹤0.01）.[Conclusion] There is a significant difference in PON2 genotype between Han and Li nationality,which needs further evidences on the different mechanisms in various ethnic groups.

关 键 词：对氧磷酶2 遗传多态性 群体遗传 

分 类 号：R541.4[医药卫生—心血管疾病]