骨组织工程脱细胞骨基质的研究进展及存在问题  

Study on acellular bone extracellular matrix and its existing problems

作　　者：尹来波[1] 刘维钢[2] 

机构地区：[1]石河子大学医学院人体解剖学教研室,新疆石河子832002 [2]新疆生产建设兵团总医院骨科,新疆乌鲁木齐830000

出　　处：《现代生物医学进展》2010年第11期2161-2163,2107,共4页Progress in Modern Biomedicine

基　　金：新疆兵团博士基金项目(NO.200406)

摘　　要：随着骨科学的发展,骨组织缺损治疗这一难题尤显突出,急需一种更为有效的疗法。骨组织工程是采用组织工程学的原理与方法,研制具有修复骨缺损能力的骨替代物的一门科学。经过20余年的发展,骨组织工程最终确立了将骨再生相关分子、成骨活性细胞与支架材料三者复合来构建组织工程骨的基本模式。支架材料是骨组织工程的核心,而作为支架材料之一的脱细胞骨基质(Acellular bone extracellular matrix,ABECM),近年来发展迅猛,展示出强大的生命力及临床应用前景。并且ABECM已有应用于临床试验的报道。本文将就此做一综述。As the development of orthopaedics and tranmstology, treatment of bone defect is a major puzzle, and is so apparent that we need a more effective therapeusis urgently.Bone tissue engineering is a Science that it adopt Tissue Engineering＇s principle and method to triturate bone surrogate which has ability to repair bone defect.With the development in recent 20 years, the basic pattern of tissue engineered bone has already been constructed, consisting of related molecules to bone regeneration, active cells for osteogenesis and scaffold materials.Scaffold materials are the core of bone tissue engineering, and the acellular bone extracellular matrix（ABECM） is one of it.ABECM developed swift for the past few years and it displayed powerful vitality and clinical application.There have been reports about clinical trials of ABECM.This article will discuss at this point.

关 键 词：骨组织工程 脱细胞骨基质 支架材料 

分 类 号：Q819[生物学—生物工程] R318[医药卫生—生物医学工程]