胰岛素乳膏的处方筛选及对创伤模型家兔愈合的影响研究  

Formulation Screening of Insulin Cream and Its Effects on Skin Injury in Model Rabbits

作　　者：周颖[1] 薛小燕[1] 侯征[1] 白卉[1] 陈瑛瑛[1] 罗晓星[1] 

机构地区：[1]第四军医大学药学系,西安市710032

出　　处：《中国药房》2010年第25期2342-2344,共3页China Pharmacy

摘　　要：目的:筛选、制备胰岛素乳膏并研究其对家兔皮肤创面的促愈合作用。方法:以外观性状和稳定性等为评价指标,优选不同基质组成的8个处方;建立家兔创伤模型,设立基质组、空白组及胰岛素乳膏小、中、大剂量组,比较各组创面愈合率和愈合时间。结果:以白凡士林、十六醇、单硬脂酸甘油酯和甘油等基质组成的处方5外观性状及稳定性较好;与基质组比较,胰岛素乳膏能显著提高各监测时间点的创面愈合率(P<0.05)并缩短创面愈合时间(P<0.05)。结论:筛选处方后所制胰岛素乳膏质量符合要求,其局部应用后可促进家兔创面的愈合。OBJECTIVE：To screen formulation of Insulin cream and to investigate the effects of insulin cream on wound healing in rabbits.METHODS：The best formulation of insulin cream was selected from 8 kinds of formulations with appearance and stability as index.Rabbit trauma model were induced and divided into matrix group,blank group,Insulin cream groups（high-dose,medium-dose and low-dose）.Wound healing rate and healing time were compared among those groups.RESULTS：The fifth formulation possessed good appearance and stability,which included albolene,cetanol,glycerin monostearate,glycerol,etc.Compared with matrix group,the wound healing rates were obviously increased at different time points in Insulin cream groups（P〈0.05）,and the wound healing period was significantly shortened（P〈0.05）.CONCLUSION：The quality of optimized insulin scream conform with the standard.Local application of Insulin cream improves wound healing in rabbits.

关 键 词：胰岛素 乳膏 基质 处方筛选 创面愈合 家兔 

分 类 号：R965[医药卫生—药理学] R977.15[医药卫生—药学]