产后抑郁患者血清催乳素、孕酮水平的变化  

The Levels of Serum Progesteroue and Prolactin in Postpartum Depression

作　　者：刘红蕾[1] 丁蓉[1] 贺红云[1] 

机构地区：[1]深圳市妇幼保健院妇女健康中心,广东深圳518048

出　　处：《南华大学学报（医学版）》2010年第4期534-536,共3页Journal of Nanhua University(Medical Edition)

摘　　要：目的研究产后抑郁患者血清催乳素、孕酮水平的变化。方法采用病例对照研究方法,对产后3天正常的213名产妇于产后42天、6个月进行随访,根据汉密尔顿抑郁量表和爱丁堡产后抑郁量表测评结果将产妇分为抑郁组及对照组,并分别于产后3天、42天和6个月采用化学发光法测定其血清催乳素和孕酮水平。结果与对照组比较,产后3天抑郁组催乳素、孕酮水平差异有显著性(t分别为2.77和6.39,P<0.05);产后42天抑郁组催乳素、孕酮水平差异有显著性(τ=3.17和2.89,P<0.05);产后6个月抑郁组血清催乳素水平差异仍有显著性(t=2.20,P<0.05)。结论产后低催乳素、孕酮水平可能为产后抑郁的发病原因之一,监测产妇产后血清催乳素和孕酮浓度对预测及治疗产后抑郁有一定的指导意义。Objective To explore relationships of postpartum depression （PPD）with serum progesteroue （ P ）and prolaetin（ PRL） levels. Method A case -control study method was used. 736 healthy parturients in 3 days after delivery were followed up respectively at 42 days and 6 months after delivery and were assessed with Edinburgh postnatal depression seale （ EPDS ）, Hamilton depression scale（ HAMD ） and general information questionnaires. The parturients with postpartum depression were divided into case group and control group aceording to their scores in EPDS and HAMD. The levels of PRL and P in the ease group and the control group were detected at 3 days ,42 days and 6 months after delivery. All data were analyzed by using SPSS/PC 10.0 software. Results At 3 days after delivery,there were siguifieant difference in serum P level and serum PRL level between the two groups （ t = 2.77 and 6.39 respectively ） ; at 42 days after delivery, in serum P level and PRL level, there were signifieant differenees between the two groups （ t = 3.17 and 2.89 respectively, both P 〈 0. 05 ）. Conclusion The lowered serum PRL and P levels may be one of the reasons that induce postpartum depression. Monitoring the serum PRL and P concentrations of parturients is of important guiding significance for predicting and treating postpartum depression.

关 键 词：产后抑郁 催乳素 孕酮 内分泌失调 

分 类 号：R714[医药卫生—妇产科学]