脓毒性脑病患儿血清S—100B及神经元特异性烯醇化酶检测的意义  

The detection of S2100β protein and NSE in patients with neuron--specific enolase and its significance

作　　者：夏汉兵[1] 刘喜[1] 刘方[1] 陆必森[1] 周刚[1] 

机构地区：[1]广东省深圳市宝安区妇幼保健院,518133

出　　处：《医学信息（下旬刊）》2010年第7期3-3,共1页Medical information

摘　　要：目的：探索脓毒性脑病（SAE）患儿血清S-100B蛋白与神经元特异性烯醇酶的水平与脑损伤的关系及其临床意义。方法：选择42例SAE为研究组，依据脓毒性脑病诊断标准分为早期和晚期病例，选择30例健康儿童为对照组。检测血清NSE及S100B蛋白水平，分析两组血清NSE及S100B蛋白水平之间的差异，并与对照组进行比较。结果：两期SAE血清NSE及S100B蛋白浓度明显高于对照组（P〈0．01），且两期SAE之间存在显著性差异。结论：早期检测NSE及S100B蛋白水平对于预脑损伤有重要意义。Objective：To explore the relationship between the expression and clinical significance of serum markers of earlybrain injury, neuron- specific enolase （NSE） and S100B protein in children with sep tie encephalopathy（SAE）. Methods According to the diagnostic criteria of SAE, 42 cases with SAE were divided into two groups with cases in early stage and ones in late stage, and 30 healthy children were selected as control group at the same time. Serum NSE and S100B protein levels were detected, and the differences of NSE and S100B protein between the two group s were analyzed. Results The levels of NSE and S--100B in the two group s with SAE were obviously higher than those in control group （ P 〈0. 01） , and there were significant differences in serum concentrations of NSE and S--100B between the two groups. Conclusion There is significant of detecting serum neuron -- specific enolase and S100B protein in children with sep ticencephalopathy, which may be useful for early diagnosis and intervention of the disease.

关 键 词：脓毒性脑病 神经元特异性烯醇酶 S100B蛋白 

分 类 号：R651.15[医药卫生—外科学]