冠心病患者的EDF昼夜节律与健康人的比较  

THE DIFFERENCES OF CIRCANDIAN RHYTHM OF SERUM EDF BETWEEN PATIENTS WITH CORONARY HEART DISEASES AND HEALTHY PEOPLE

作　　者：史晓红[1] 张培荣[1] 李静宇[1] 尚红 张善亮[1] 

机构地区：[1]河南省郑州市河南省人民医院

出　　处：《河北医学》1999年第1期49-51,共3页Hebei Medicine

摘　　要：目的：了解冠心病人血中内生洋地黄因子（ＥＤＦ）水平是否存在２４ｈ节律性变化及这种变化的特征和意义；方法：用放免法对２０例冠心病人和９例“健康人”进行了２４ｈ血中ＥＤＦ的动态监测；结果：发现冠心病患者血清ＥＤＦ浓度有着与健康同龄人明显不同的昼夜节律性变化，其峰值在７：００，谷值在１９：００，两者差别悬殊；结论：在对冠心病患者应用洋地黄类药物和检测血清地高辛浓度时，必须考虑到其ＥＤＦ的这种特殊的变化规律。ＥＤＦ的昼夜节律性变化可能与冠心病的夜间阵发性呼吸困难、心绞痛等的发作有关联。Objective: To know whether or not there is a circandian of serum Endogenous Digitalis like Factor(EDF)in patients with coronary heart disease(CHD),We conducted the study as follows. Method: The levels of serum EDF of 20 patients with CHD and 9 healthy people were dynamically determined for 24 hours. The differences between them were analysed.Results: we found that there is a circandian variation of serum EDF in patients with Coronary Heart Disease(CHD),which is obviously different from healthy people .The peak value of the patients′ serum EDF arises at 7:00,the valley value at 19:00.these two values differ greatly.Conclusion: We must consider the circandian rhythm of serum EDF when using medicine like digitalis and determinating level of Digoxin in serum.The circandian variations of EDF in patients with CHD are likely relevant with paroxysmay cnocturnal dyspnea and other heart attacks.

关 键 词：冠心病 昼夜节律 洋地黄 EDF 

分 类 号：R541.402[医药卫生—心血管疾病]