布鲁氏菌外膜蛋白的研究进展  

Progress in research on outer membrane proteins of Brucella

作　　者：胡剑飞[1,2] 崔步云[2] 关平原[1] 刘志国[1,2] 

机构地区：[1]内蒙古农业大学,呼和浩特010018 [2]中国疾病预防控制中心传染病预防控制所,北京102206

出　　处：《疾病监测》2010年第5期380-389,共10页Disease Surveillance

基　　金：863课题;布鲁氏菌快速诊断技术标志性抗原研究(No.2007AA02Z410)~~

摘　　要：布鲁氏菌的外膜包括脂多糖、外膜蛋白和磷脂层。其中外膜蛋白是布鲁氏菌的主要免疫原和保护性抗原。根据分子质量的大小,将外膜蛋白分为3组。第一组有外膜蛋白10 k、18 k、19 k,其中Omp10、Omp16和Omp19为一种脂蛋白。第2组包括36 k～38 k外膜蛋白。第3组包括31 k～34 k外膜蛋白和25 k～27 k外膜蛋白,Omp25和Omp31与布鲁氏菌的毒力和免疫原性有密切关系。本文就这3组外膜蛋白的研究进行了总结。The outer membrane of Brucella spp is mainly composed of Lipopolysaccharide,outer membrane proteins and phospholipid.The major outer membrane proteins of Brucella spp.are characterized as potential immunogen and protective antigens.They are classified according to their molecular mass into three groups,the group 1 proteins which consists of 10 k,18 k and 19 k.In this group,Omp10,Omp16 and Omp19 are lipoproteins.36-38 k OMPs are group 2 proteins,and 31-43 k and 25-27 k OMPs belong to the group 3 proteins,Omp25 and Omp31 are closely related to the virulence and immunogenicity of Brucella.This paper will summarize the research on these three groups of outer membrane proteins.

关 键 词：布鲁氏菌 外膜蛋白 抗原性 免疫原性 

分 类 号：R516.7[医药卫生—内科学]