肺炎并心力衰竭患儿血浆尾加压素Ⅱ与肌钙蛋白Ⅰ、左室射血分数的关系  

Relationship between plasma urotensin Ⅱ and cardiac troponin Ⅰ,left ventricular ejection fraction in infant with pneumonia complicated congestive heart failure

作　　者：颜萍[1] 韩秀珍[2] 樊青[1] 张晓静[1] 

机构地区：[1]济南市妇幼保健院儿科,山东济南250001 [2]山东省立医院儿科,山东济南250021

出　　处：《中国优生与遗传杂志》2010年第7期15-17,共3页Chinese Journal of Birth Health & Heredity

基　　金：济南市卫生局科研资助项目(2006-23);济南市科技局科学技术发展计划项目(066027)

摘　　要：目的探讨肺炎并心力衰竭患儿血浆尾加压素Ⅱ(UⅡ)水平与肌钙蛋白(cTnI)、左室射血分数(LVEF)的关系及其临床意义。方法选择肺炎并心衰组、普通肺炎组、健康对照组各30例,放射免疫法检测各组血浆UⅡ含量,并检测cTnI及肌酸激酶心肌同工酶(CK-MB),多普勒超声心动图测定患儿的LVEF反映心功能变化,其中肺炎并心衰组有20例治疗后复测UⅡ、cTnI、CK-MB、LVEF。结果肺炎并心衰组与普通肺炎组及健康对照组比较,血浆UⅡ含量、cTnI及CK-MB显著升高,LVEF显著下降(P<0.05),心衰治疗后血浆UⅡ含量、cTnI及CK-MB下降显著(P<0.05),LVEF显著升高(P<0.05),肺炎并心衰组治疗前血浆UⅡ与cTnI、CK-MB呈显著正相关,与LVEF呈显著负相关,UⅡ与LVEF的线性回归方程为y=-4.43x+83.673。结论 UⅡ参与肺炎并心衰的病理生理过程,血浆尾加压素Ⅱ的含量可反映心功能的程度,通过UⅡ与LVEF的线性回归方程计算出LVEF,血浆UⅡ可作为心力衰竭的定量诊断指标,肺炎并心力衰竭时血浆尾加压素Ⅱ的升高与心肌损害有关。Objective：To investigate the relationship between plasma urotensin Ⅱ（UⅡ）and cardiac troponin I（cTnI）,left ventricular ejection fraction （LVEF）in infant with pneumonia complicated congestive heart failure and their clinical significance.Methods：30 sampled were taken from infants patients with pneumonia complicated with heart failure,infants patients with common pneumonia and normal infants,respectively.plasma U II levels were determined by radioimmunoassay,cTnI and CK-MB were measured,too.LVEF were measured by Doppler ultrasonography to reflect the changes of heart function.The levels of U II,cTnI,CK-MB and LVEF were determined again in 20 infants patients with pneumonia complicated with heart failure after the treatment.Results：In comparison with the infants with pneumonia and the normal infants,The levels of UII,cTnI and CK-MB were significantly higher,while the LVEF were significantly decreased in the infants with pneumonia complicated CHF（P〈0.05）,After treatment,The levels of UII,cTnI and CK-MB in infants with pneumonia complicated with heart failure decreased significantly（P〈0.05）,LVEF increased significantly（P〈0.05）,Before treatment,UII correlated positively with cTnI and CK-MB.U II correlated negatively with LVEF.The linear regression equation for UⅡ and LVEF was y =-4.43x ＋ 83.673.Condusions：UII is involved in the pathophysiology of pneumonia complicated with heart failure.The concentration of plasma U II reflects the level of heart function,LVEF is calculated by the linear regression equation for UⅡ and LVEF,plasma UⅡcan be used as quantitative diagnosis index of heart failure.The increase of U II in patients with pneumonia complicated with heart failure is related to myocardial damage.

关 键 词：肺炎 心力衰竭 尾加压素Ⅱ 肌钙蛋白Ⅰ 左室射血分数 

分 类 号：R725.6[医药卫生—儿科]