新生儿乙肝疫苗接种后的免疫效应  

The immunity effect of after the neonates were inoculated the hepatitis B vaccine

作　　者：陈红[1] 李亚平[1] 卢新[1] 

机构地区：[1]北京市海淀区妇幼保健院儿科,北京100080

出　　处：《中国优生与遗传杂志》2010年第7期83-84,80,共3页Chinese Journal of Birth Health & Heredity

基　　金：北京市卫生局妇幼科研基金资助项目(C03011403)

摘　　要：目的探讨新生儿乙肝疫苗接种后的免疫效应的持久时间。方法对新生儿计划免疫后2岁至4岁的儿童进行乙肝表面抗体(HBsAb)定量检验,分2岁组和3-4岁组(3岁组和4岁组)观察各组儿童HBsAb定量差异。结果①2岁组50例儿童HBsAb定量平均为949.908±1440.9mU/ml,3-4岁组181例儿童HBsAb定量平均为62.3±104.0mU/ml,经统计学处理2岁组与3-4岁组儿童HBsAb定量比较差异非常显著(t=4.353,P=0.000)。②3岁组90例儿童HBsAb定量平均为70.8±125.7mU/ml,4岁组91例儿童HBsAb定量平均为53.8±76.5mU/ml,经统计学处理3岁组与4岁组儿童HBsAb定量比较差异不显著(t=1.104,P=0.271)。③2岁组50例儿童无HBsAb定量小于10mU/ml(为阴性),(HBsAb阳性率为100%);3-4岁组HBsAb定量小于10mU/ml53例,HBsAb阴性率为29.3%。④2岁组HBsAb低定量发生率为24%;3-4岁组HBsAb低定量发生率为81%;经统计学处理2岁组与3-4岁组HBsAb低定量发生率比较差异非常显著(χ2=64.823,P=0.000)。结论 3-4岁儿童乙肝表面抗体高阴性率和高低定量发生率提示应该在出生后3-5年加强一次乙肝疫苗。Objective：To study the durative time of the immunity effect of after the neonates were inoculated the hepatitis B vaccine. Methods：During 2 years to 4 years after the neonates were inoculated the hepatitis B vaccine children were tested the hepatitis B surface antibody quantification. The children were divided into 2years group and 3-4 year group（3year group and 4year group）.Results：①In the 2 years group there were 50 children,their the hepatitis B surface antibody average quantification was 949.908±1440.9mU/ml.In 3-4 years group there were 181 children whose the hepatitis B surface antibody average quantification was 62.3±104.0mU/ml.Both difference was very marked（t=4.353,P=0.000）. ② In the 3 group there were 90 children whose the hepatitis B surface antibody average quantification was 70.8±125.7mU/ml.The the 4 group there were 91 children whose the hepatitis B surface antibody average quantification was 53.8±76.5mU/ml. Both difference was not marked（t=1.104,P=0.271）.③In the 2 year group there was no child whose the hepatitis B surface antibody quantification was less than 10mU/ml（negative）,（the positive rate was 100%）.In the 3-4 years group there were 53 children whose the hepatitis B surface antibody quantification was less than 10mU/ml（negative）.④In the 2years group there was 12 children whose the hepatitis B surface antibody quantification was lower than 94.9mU/ml,the lower antibody rate was 24%. In the 3-4 years group there were 150 children whose hepatitis B surface antibody quantification was lower than 94.9mU/ml,the lower antibody rate was 81%. Both difference was very marked（χ2=64.823,P=0.000）.Conclusion：In 3-4 years children the higher negative rate of the hepatitis B surface antibody and the high of the antibody lower rate prove should again inoculated the hepatitis B vaccine at 3-5years after born.

关 键 词：新生儿 乙肝疫苗 免疫效应 

分 类 号：R186[医药卫生—流行病学]