肺结核并发肺部真菌感染的易感因素分析  

Analysis on susceptible factors in patients with pulmonary tuberculosis complicated by fungal infection

作　　者：汪长生[1] 杨进孙[1] 都郭蕾[1] 

机构地区：[1]皖南医学院附属弋矶山医院感染科,芜湖241001

出　　处：《中国防痨杂志》2010年第7期380-383,共4页Chinese Journal of Antituberculosis

摘　　要：目的探讨肺结核并发肺部真菌感染的易感因素。方法收集2008年7月—2009年7月皖南医学院附属弋矶山医院收治的522例肺结核临床资料,以并发肺部真菌感染54例为观察组,未并发肺部真菌感染468例为对照组,进行回顾性分析。结果观察组与对照组在性别、年龄、体质量指数、临床类型、是否长期使用广谱抗生素、是否应用糖皮质激素、有无糖尿病、痰涂片抗酸染色情况等指标之间的差异均有统计学意义(P<0.05)。通过多因素非条件Logistic回归分析筛选出老年人、长期使用广谱抗生素或糖皮质激素及合并糖尿病者等为易感的高危因素。结论对于老年人、长期使用广谱抗生素或糖皮质激素及合并糖尿病者更需提高警惕,必要时采取相应的预防监控措施。Objective To study the susceptible factors in patients with pulmonary tuberculosis complicated by fungal infection. Methods The clinical data of 522 patients with pulmonary tuberculosis, in which 54 cases were complicated by fungal infection （observation group）, while 468 cases were not complicated by fungal infection （control group）, were collected and analyzed retrospectively from July 2008 to July 2009. Results The involved factors of pulmonary tuberculosis complicated by fungal infection were correlated with sex, age, body mass index, clinical types, with or without the long-term use of antibiotics and glucocorticoids, diabetes mellitus and sputum smear-negative by acid-fast stain. There were significant differences in these factors between the observation group and the control group （P〈0.05）. Through the analysis with the non-conditional logistic regression, 4 risk factors for the pulmonary tuberculosis patients were screened out, they were elderly, the long-term use of antibiotics or glucocorticoids, diabetes mellitus. Conclusions The patients with elderly, the long-term use of antibiotics or glucocorticoids, diabetes mellitus need to be raised vigilance and need to be taken appropriate preventive control measures.

关 键 词：结核 肺/并发症 肺疾病 真菌性 疾病易感性 

分 类 号：R519[医药卫生—内科学]