高血流介导的肺动脉高压与核转录因子-κB的相关性  被引量:1

Correlation between Pulmonary Hypertension Induced by High Blood Flow and Nuclear Factor-κB

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作  者:于晓晓[1] 杨杰[1] 孙若鹏[1] 

机构地区:[1]山东大学齐鲁医院儿童医疗中心,济南250012

出  处:《实用儿科临床杂志》2010年第13期1020-1023,共4页Journal of Applied Clinical Pediatrics

基  金:山东省自然科学基金重点项目(Z2008C14)

摘  要:左向右分流型先天性心脏病易引发肺动脉高压,目前一致认为其机制为高血流切应力刺激肺动脉内皮细胞,启动基因转录调节,发生一系列分子生物及病理生理变化,最终导致肺血管病理性重建。核转录因子-κB(NF-κB)是一种具有多种生物学效应的核转录因子,在高血流肺血管重建中起重要作用。NF-κB信号途径可被高血流激活,其靶基因产物如血管活性介质、细胞因子等使肺血管难以维持正常结构,引起病理性收缩和重建,从而使肺动脉压力升高。Congenital heart disease with left -to -right shunt easily lead to pulmonary hypertension. Currently agreed about its mechanism:shear stress induced by high pulmonary blood flow stimulus pulmonary endothelium,to start regulation of genetic transcription,to initiate a series of molecular biology and pathophysiology changes,and finally to lead to pulmonary vascular pathologic remolding. Nuclear factor(NF) - κB is a kind of nuclear factor with muhiple biological effect and play an important role in puhnonary vascular remolding. NF - κB signal can be actiacted by high blood flow. Its target gene products, for example, vasoactive mediators, cytokines, make pulmonary vessels difficulty to maintain the normal structure and cause pulmonary vascular contraction and remolding,thus, pulmonary arterial pressure increases.

关 键 词:心脏病 先天性 肺动脉高压 肺血管重建 核转录因子-ΚB 

分 类 号:R541.1[医药卫生—心血管疾病]

 

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