大剂量化疗联合自体外周血干细胞移植治疗非霍奇金淋巴瘤临床观察  

High-dose therapy and autologous peripheral blood stem cell transplantation treatment on Non-Hodgkin lymphoma

作　　者：左雨娜 袁朝晖[1] 胡国瑜[1] 

机构地区：[1]湖南省株洲市一医院血液内科,湖南株洲412000

出　　处：《中国现代医学杂志》2010年第10期1591-1593,1596,共4页China Journal of Modern Medicine

摘　　要：目的观察非霍奇金淋巴瘤在常规化疗后用大剂量化疗联合自体外周血干细胞移植(APBSCT)作为巩固治疗方法的初期疗效。方法 28例非霍奇金淋巴瘤患者分为对照组和移植组,每组14例。对照组采用CHOP、CHOEP或COAP方案常规化疗6个疗程;移植组在对照组基础上,加以大剂量化疗联合自体外周血干细胞移植(APBSCT)治疗。移植组在常规化疗6个疗程后,以大剂量环磷酰胺联合G-CSF动员,以长春瑞滨+米托蒽醌+环磷酰胺+阿糖胞苷方案预处理。结果随访2～5年,对照组有6例完全缓解,3例复发,死亡6例。移植组有12例完全缓解,3例复发,其中1例死于淋巴瘤复发疾病进展。移植组所有患者移植后造血功能均快速重建。中性粒细胞大于0.5×109个/L和PLT>20×109个/L,所需时间分别为12和18d。两组的毒副作用差异无显著性。结论以大剂量化疗联合自体外周血干细胞移植治疗非霍奇金淋巴瘤,安全性高且疗效较好。[Objective]To evaluate the initial therapeutic effect of high-dose chemotherapy and autologous peripheral blood stem cell transplantation after six courses of CHOP plan treatment on Non-Hodgkin lymphoma. [Methods]Twenty eight patients with Non-Hodgkin lymphoma were divided into two groups, the control group and the transplantation group medially. the control proup was treated with six courses of CHOP or CHOEP or COAP plan, the transplantation group was treated with high-dose therapy and autologous peripheral blood stem cell transplantation after six courses of CHOP plan, Hematopoietic stem cells were mobilized and collected by granulocyte colony stimulating factor （G-CSF） combined with high-dose cyclophosphamide. The conditioning regimen was Vinorelbine Tartrate, Mitoxantrone,cyclophosphamide, cytarabine. [Results]Follow-up 2-5 years, the control group CR 6 cases, recured 7 cases, and died 6 cases, which were markedly lower than that of the transplantation group’s 12, 3 and 1 cases accordingly, the transplantation group had quickly reconstitute bone marrow hematopoiesis post transplant.When the number of heterophil granulocyte exceed 0.5×109/L, and the number of PLT20×109/L, the times were 12 and 18 d respectively. Side effects of two groups had no significance.[Conclusion]It is safe and good curative effect that high-dose therapy and autologous peripheral blood stem cell transplantation treat on Non-Hodgkin lymphoma.

关 键 词：非霍奇金淋巴瘤 自体外周血干细胞移植 大剂量化疗 

分 类 号：R825.5[医药卫生—临床医学]