阿莫西林克拉维酸钾联合雷贝拉唑钠治疗儿童幽门螺杆菌阳性胃病疗效与安全性观察  

Efficacy and safety of amoxicillin and clavulanate for oral suspension combined with rabeprazole for helicobacter pylori eradication in children

作　　者：朱黎明 

机构地区：[1]洛阳市机车医院中西医结合科,河南洛阳471002

出　　处：《中国实用儿科杂志》2010年第7期545-548,共4页Chinese Journal of Practical Pediatrics

摘　　要：目的比较10d序贯疗法(包括雷贝拉唑、阿莫西林克拉维酸钾干混悬剂、克拉霉素)和7d传统三联疗法(包括奥美拉唑、阿莫西林、克拉霉素)治疗儿童幽门螺杆菌(Hp)阳性胃病的疗效和安全性。方法将2006年10月至2009年8月洛阳市机车医院123例Hp阳性胃病患儿随机分为两组,对照组(41例)进行7d传统三联疗法,治疗组(82例)给予10d序贯疗法。疗程结束7～10d后检查消化性溃疡愈合情况和Hp清除率,评估症状积分和副反应。结果溃疡愈合率对照组为40%,治疗组为55.5%,差异有统计学意义(P<0.05)。Hp清除率治疗组为92.68%,对照组为70.73%,差异有统计学意义(P<0.05),治疗组症状总积分治疗前为(56.89±4.32)分,治疗后为(14.96±2.13)分;对照组症状总积分治疗前为(58.75±5.12)分,治疗后为(21.42±3.78)分,两组症状总积分治疗后较治疗前均有显著下降(P<0.05或P<0.01),治疗组变化更为明显(P<0.01)。治疗组副反应低于对照组(6.1%对17.1%,P>0.05)。结论包括雷贝拉唑、阿莫西林克拉维酸钾干混悬剂及克拉霉素的10d序贯疗法治疗儿童Hp阳性胃病比7d传统三联疗法更有效。Objecive To compare the efficacy and safety of 10-day sequential treatment（including rabeprazole, amoxicillin and clavulanate for oral suspension,clarithromycin） and 7-day traditional trigeminy therapy （including omeprazole, amoxicillin and clarithromycin） for the eradication of helicobacter pylori（HP）in children. Methods From Oct.2006 to Aug.2009,123 children with gastropathy with Hp infection,in Luoyang Locomotive Hospital of Henan,were divided into two groups.The control group （41） was treated with traditional trigeminy therapy for 7 days,while the treatment group（82）was treated with 10-day sequential treatment.Cure rates of the ulcer healing and Hp eradication were assessed after treatment course of 7-10 days,while the symptom scores and the side effect were evaluated and investigated after the treatment. Results The healing rate of ulcer in control group was 40%（2/5）,which was 55.5%（5/9） in the treatment group,the difference being statistically significant（P〈0.05）. The Hp eradication rate was 92.68%（76/82）and 70.73%（29/41）in treatment group and control group, respectively .There was significant statistical difference（P〈0.05）. The total symptom score of treatment group before treatment was（56.89±4.32）, and after treatment it was （14.96±2.13）,while that of control group before treatment was （58.75 ± 5.12） and （21.42 ± 3.78） after treatment（P〈0.05 or P〈0.01）,the change of treatment group being more significant（P〈0.01）. The side effect rate of treatment group was lower than that of control group （6.1% VS 17.1%,respectirely,P〉0.05）. Conclusion The 10-day sequential treatment,including rabeprazole,amoxicillin and clavulanate for oral suspension and clarithromycin,is much more efficient with lower side effect than 7-day traditional trigeminy therapy for Hp eradication in children with gastropathy with Hp infection.

关 键 词：阿莫西林克拉维酸钾干混悬剂 雷贝拉唑钠 幽门螺杆菌 儿童 

分 类 号：R72[医药卫生—儿科]