人巨细胞病毒小鼠脑内感染的病理变化  

Dynamic pathological observation of HCMV infection in brain mice

作　　者：黎辉[1] 李天宪[1] 陈家禄[1] 

机构地区：[1]湖北医科大学附一院病理科

出　　处：《卒中与神经疾病》1999年第1期36-37,共2页Stroke and Nervous Diseases

摘　　要：采用人巨细胞病毒直接注入小鼠大脑，通过组织化学及ＨＥ染色，光镜观察结果显示：ＢＡＣＢ／Ｃ鼠病变显现率６０．６９％，昆明鼠是３０．３０％。小鼠脑组织以海马区，侧脑室病变明显，病变特点是脑内血流循环障碍而导致脑软化。提示：人巨细胞病毒严重感染的新生儿在发育过程中出现一系列神经系统障碍可能与病毒损害患儿海马区，侧脑室神经细胞有关。HCMV was directly injected into the brain of both Kumin and BACB/L mice and pathological changes were observed by light microscope and HE staining in the study.The results showed that 60.6% of BALB/C miceand 30.30% Kuming mice had obvious pathological changes.The basic change was inflammation which was mainly observed in the nerve tissue of hippocampal gyrus.Circulation obstruction in the blood vessles of changed brain tissue resulted in encephalomalacia and sporatic calcification.The results indicated that a series ofnerve system abnormalities occured in newborns with severe HCMV infection duringtheir development may be probably caused by the damages of nerve tissue at hippocampal gyrus.

关 键 词：人巨细胞病毒 脑内接种 病理 儿童 

分 类 号：R512.302[医药卫生—内科学] R373.11[医药卫生—临床医学]