CEDIA法测定地高辛浓度的实验观察与临床应用  

EXPERIMENTAL OBSERVATION AND CLINICAL APPLICATION OF MEASUREMENT OF DIGOXIN CONCEN TRATION BY CEDIA

作　　者：郭绍丽[1] 蔡忠[1] 马凤英[1] 

机构地区：[1]天津市胸科医院

出　　处：《天津医科大学学报》1999年第1期68-69,共2页Journal of Tianjin Medical University

摘　　要：目的：应用克隆酶免疫分析（ＣＥＤＩＡ）技术测定地高辛浓度，指导临床科学用药。方法：克隆酶免疫分析技术。结果：与放射免疫分析方法（ＲＩＡ）进行相关实验，结果ｒ＝０．９２６５相关良好。检测２０６例患者，非中毒病人１５１例，中毒病人５５例，其中１０例病人临床表现为地高辛中毒症状，血中地高辛浓度测定９例高于正常，诊断符合率９０％。结论：该方法稳定、方便、快速，实验数据与临床表现基本吻合。Objective:To Apply CEDIA for measuring digoxin concentration and directing treatment with clinical drugs Methods:CEDIA Results: A good correlation was shown as compared with the RIA method( r= 0 9265) Digoxin concentration was determinated in 206 patients 151 cases were non toxic group and 55 cases in the toxic group were toxic, 9 of 10 patients suffering from digoxin toxicosis were found with higher level of digoxin concentration than nomal cases The positive rate is 90% Conclusion:The CEDIA is stable,simple and rapid, the result of this method corresponds to the clinical manifestation of patients detected and it can be used for detecting digoxin toxicois , and especially used in emergency cases

关 键 词：药物监测 地高辛浓度 克隆酶免疫法 

分 类 号：R972.1[医药卫生—药品] R969[医药卫生—药学]