复发性卵巢上皮癌再次手术预后因素系统评价  

Systematic review of prognosis factors after secondary surgery in recurrent ovarian cancer.

作　　者：刘丽萍[1] 吴小华 

机构地区：[1]河北定州市武警8640部队医院妇产科,河北定州073000 [2]河北石家庄市白求恩国际和平医院妇科,河北石家庄050082

出　　处：《中国实用妇科与产科杂志》2010年第7期534-536,共3页Chinese Journal of Practical Gynecology and Obstetrics

摘　　要：目的探讨复发性卵巢上皮癌再次肿瘤细胞减灭术的预后因素及病例选择标准。方法采用系统评价的方法,收集国内外2003年1月至2007年12月公开发表的二次手术治疗复发性卵巢癌的临床资料,进行分析。制定严格的纳入和排除标准。将可能影响再次肿瘤细胞减灭术中位生存期的预后因素进行定性评价。结果 12篇文献符合纳入标准。具有统计学意义的预后因素包括复发灶的多少、无疾病进展期(DFI)长短、初次手术残余灶大小、最大复发灶的直径,腹水的有无,再次手术残余灶大小。结论满足良好预后的因素为:(1)孤立的复发灶。(2)DFI≥12个月。(3)初次手术时达到理想的肿瘤细胞减灭术。(4)复发时腹水≤500mL。(5)进行了理想的再次肿瘤细胞减灭术。Objective To evaluate the prognosis factors of secondary cytoreductive surgery （SCS） and develop a selection standard, in order to supply evidences for selecting patients. Methods A systematic review was performed to analyze clinical trials of secondary surgery of recurrent ovarian cancer that published in public at home and abroad between January 2003 and December 2007. Inclusion criteria and exclusion criteria were established. The factors may affect the patients＇prognosis after SCS were assessed. Results Twelve trials were included. A significant difference in median survival was found for the variables： number of recurrent tumors, size of maximum tumor, disease-free interval, residual tumor at PCS, residual tumor at SCS, massive ascites. Conclusion The factors that can improve median survival after SCS include ： number of recurrent tumors, disease-free interval, residual tumor at PCS, residual tumor at SCS, massive ascites.

关 键 词：复发性卵巢上皮癌 再次肿瘤细胞减灭术 中位生存期 系统评价 定性评价 

分 类 号：R71[医药卫生—妇产科学]