人绒毛膜促性腺激素注射日卵泡大小与体外受精-胚胎移植妊娠率的关系  

The relationship between the follicular diameter on the day of HCG administration and pregnancy rate of in vitro fertilization and embryo transfer.

作　　者：方媛媛[1] 王秀霞[1] 

机构地区：[1]中国医科大学附属盛京医院妇产科辅助生殖中心,辽宁沈阳110004

出　　处：《中国实用妇科与产科杂志》2010年第7期543-545,共3页Chinese Journal of Practical Gynecology and Obstetrics

基　　金：辽宁省自然科学基金(20072118)

摘　　要：目的探讨体外受精-胚胎移植(in vitro fertilization and embryo transfer,IVF-ET)的控制性超促排卵(COH)周期中人绒毛膜促性腺激素(HCG)注射日卵泡径线与妊娠率的相关性。方法回顾性分析2008年1月至2009年6月首次在中国医科大学附属盛京医院接受IVF-ET或卵胞浆内单精子注射-胚胎移植(ICSI-ET)治疗的患者共364周期,并根据HCG日最大卵泡径线分为:A组(14≤D≤16 mm),B组(16.5≤D≤17 mm),C组(17.5≤D≤18 mm),D组(18.5≤D≤20mm)和E组(D>20 mm)来分析HCG日的卵泡径线与妊娠结局的关系。结果 5组妊娠率分别为50.00%,64.29%,57.01%,33.33%,29.78%,差异有统计学意义(P<0.05)。随着组别的升高,促性腺激素(Gn)使用时间延长,但获卵数、受精率、卵裂率和优质胚胎占有率差异无统计学意义(P>0.05)。结论体外受精-胚胎移植治疗COH周期中,主导卵泡径线在14～18 mm时决定HCG注射可以得到较高的临床妊娠率,当卵泡经线超过18mm时,胚胎继续发育潜能降低,临床妊娠率降低。Objective To study the relationship between follicular diameter on the day of HCG administration and pregnancy rate during controlled ovarian stimulation（COH） in in vitro fertilization and embryo transfer. Methods The study groups included 364 cases who received ovarian stimulation cycle in the Affiliated Shengjing Hospital of China Medical University between January 2008 and June 2009. All the patients were divided into 5 groups by reviewed the leading follicular diameter on the day of HCG administration： A （ 14 ≤ D ≤ 16 mm）, B （ 16. 5≤D ≤17 mm）, C （ 17.5 ≤ D ≤ 18 mm） ,D （18.5≤D≤20mm）. Results The pregnancy rates of the five groups were 50.00%, 64.29%, 57.01%, 33.33% ,29. 78% respectively,there was significant differenee（P 〈 0. 05）. The higher the groups got the longer the administration of gonadotropin. However, there were no differences between groups on the oocytes collected rate, fertilization rate, cleavage rate and presence rate of good quality embryo. Conclusion In COH cycles, we can get higher pregnancy rate when the leading follicular diameter is between 14 and 18mm on the HCG administration day. When the leading follicular diameter is lager than 18mm,the development ability of embryos declines and the pregnancy rate declines.

关 键 词：卵泡径线 体外受精-胚胎移植 妊娠率 

分 类 号：R71[医药卫生—妇产科学]