动态动脉硬化指数在原发性高血压患者中的初步临床研究  

Preliminary clinical study of ambulatory arterial stiffness index in patients with primary hypertension

作　　者：张瑞华[1] 秦明照[1] 

机构地区：[1]首都医科大学附属北京同仁医院干部医疗科,100730

出　　处：《中华老年心脑血管病杂志》2010年第7期584-586,共3页Chinese Journal of Geriatric Heart,Brain and Vessel Diseases

摘　　要：目的探讨原发性高血压患者的动态动脉硬化指数(AASI)在心脑血管疾病及靶器官损害(肾功能不全)中的预测价值。方法选择原发性高血压患者160例,根据AASI结果,将AASI小于中位数的79例患者作为A组,大于或等于中位数的81例患者作为B组。对AASI与心血管疾病、糖尿病、肾功能不全、血脂以及24h脉压(24hPP)和24h平均动脉压(24h MAP)进行比较。结果与A组比较,B组患者合并脑卒中和心血管疾病明显增多,24h PP明显升高,肾小球滤过率明显下降(P<0.05,P<0.01)。合并脑卒中及心血管疾病患者较不合并患者AASI明显升高(P<0.01);合并脑卒中及心血管疾病患者较不合并患者24h PP也明显升高(P<0.05);有吸烟史患者较不吸烟患者24h MAP明显升高,差异有统计学意义(P<0.05)。AASI和24h PP与肾小球滤过率呈负相关(r=-0.314,P=0.000;r=-0.156,P=0.049)。结论 AASI可能是原发性高血压患者发生心脑血管疾病及肾功能不全的独立的预测因素。Objective To investigate the predictive value of AASI in cardio-eerebrovascular disease and target-organ damage（renal insufficiency） in patients with primary hypertension. Methods A total of 160 patients with primary hypertension were divided into two groups. Patients with AASI less than median were group A. Patients with AASI equal to or above the median were group B. AASI was compared with cardio-cerebrovascular disease, diabetes mellitus, renal insufficiency, blood lipid,24 h PP and 24 h MAP. Results Compared with group A,patients in group B showed higher prevalence of stroke and cardiovascular diseases,higher values of 24 h PP and reduction in glomerular filtration rate （P 〈 0.05,P 〈 0.01）. Patients with stroke or cardiovascular diseases had significantly higher AASI values compared with those without （P 〈 0.01）. Also the 24 h PP was higher in patients with stroke or cardiovascular diseases than those without （P 〈 0.05）. Patients with smoking history had significantly higher 24 h MAP values （P 〈0.05）. AASI and 24 h PP were negatively correlated to glomerular filtration rate （r =-0.314, P = 0. 000;r =-0. 156, P = 0. 049）. Conclusions AASI might be an independent predictor of cardio-cerebrovascular disease and renal insufficiency in patients with primary hypertension.

关 键 词：动脉硬化 高血压 心血管疾病 脑血管障碍 肾功能不全 危险因素 

分 类 号：R544.1[医药卫生—心血管疾病]