差示分光光度法测定阿司匹林肠溶片的含量  

Determination of aspirin enteric-coated tablets by differential spectrophtometry

作　　者：张宏祥 刘燕 

机构地区：[1]安徽省池州市药品检验所,安徽池州247000

出　　处：《安徽医药》2010年第8期901-902,共2页Anhui Medical and Pharmaceutical Journal

摘　　要：目的探讨阿司匹林肠溶片含量测定的方法。方法在波长297 nm处,阿司匹林以其在0.1 mol.L-1盐酸溶液为参比液,测得其在0.1 mol.L-1氢氧化钠溶液中的差示吸收值。结果阿司匹林浓度在10.29~30.87 mg.L-1范围内ΔA与溶液浓度呈良好线性关系（r=0.9998）,平均回收率为99.84%（n=6）,RSD为0.51%。结论该法简便、快速、准确。Aim To explore a method of determining the aspirin enteric-coated tablets. Methods The differential absorptions of Aspirin in 0.1 mol · L^-1 HCl and in 0. 1 mol · L^-1 NaOH were determined at the detection wavelength of 297 nm. Results The calibration curves show good linearity in the range between 10.29 and 30.87 mg · L^-1 （ r = 0. 9998 ）. The average recovery rate was 99.84% （ n = 6）, and RSD was 0.51%. Conclusion The method is simple, quick and accurate.

关 键 词：差示分光光度法 阿司匹林 测定 

分 类 号：R927[医药卫生—药学]