超敏C反应蛋白、脑钠肽与急性冠脉综合征的相关性研究  

High sensitive C-reactive protein,brain natriuretic peptide in acute coronary syndrome

作　　者：陈刚[1] 徐岩[1] 程自平[1] 陈斌[1] 朱润硕[1] 

机构地区：[1]安徽医科大学第一附属医院心内科,安徽合肥230022

出　　处：《安徽医药》2010年第8期914-915,共2页Anhui Medical and Pharmaceutical Journal

摘　　要：目的探讨急性冠脉综合征(ACS)患者血中超敏C-反应蛋白(hs-CRP)和脑钠肽(BNP)的含量及它们与急性冠脉综合征(ACS)的相关性。方法选取急性冠脉综合征(ACS)患者100例作为观察组,其中急性心肌梗死(AM I)组患者50例,不稳定型心绞痛(USAP)组患者50例。稳定型心绞痛(SAP)组患者30例,20例健康者作为对照组,采用乳胶增强免疫比浊法测定研究对象血清hs-CRP的浓度,用酶联免疫吸附法(ELISA)测定血浆BNP浓度。结果血中hs-CRP、BNP水平ACS组、SAP组显著高于对照组(P<0.05),ACS组显著高于SAP组(P<0.05),AM I组显著高于USAP组(P<0.05),且hs-CRP和BNP呈正相关。结论ACS患者血中hs-CRP、BNP浓度与冠心病危险程度存在明显的相关性,可以作为判断冠脉病变严重程度的重要指标。Aim To detect the levels of plasma high sensitive C-reactive protein, brain natriuretic peptide （BNP） and the correlation of the patients with acute coronary syndrome（ACS）. Methods 100 patients with ACS were divided into acute myocardial infarction（AMI） group （ n = 50 ）, USAP group （ n = 50 ）, stable angina pectoris （SAP） group （ n = 30 ）, and healthy control group （ n = 20 ） subjects matched for age,sex . The levels of plasma hs-CRP were measured with immune nephelometry. BNP were measured with enzyme-linked immunosorbent assay. Results The levels of hs-CRP, BNP in patients with ACS and SAP were significantly higher than those in control group （P 〈 0.05 ）. The levels of hs-CRP, BNP in ACS group were significantly higher than those in SAP group （ P 〈 0.05 ）. There was significant difference between the AMI and USAP groups （ P 〈 0.05 ）. The correlation between hs-CRP and BNP level was positive in ACS. Conclusion There is a significant correlation between hs-CRP, BNP and the risk level of coronary heart disease. These two indexs can evaluate the severity degree.

关 键 词：超敏C-反应蛋白 脑钠肽 急性冠脉综合征 

分 类 号：R541.4[医药卫生—心血管疾病]